Study of Qingre Liyan Decoction （清热利咽汤） in Treating and Preventing Acute Radioactive Oral Mucositis.pdfVIP

·280· Chin J lnteqr Med 2007 Dec；1 3(4)：280．284 ORIGINAL ARTICLE Study of Qingre Liyan Decoction(清热利咽汤)in Treating and Preventing Acute Radioactive Oral Mucositis wu Min—hui(吴敏慧)，YUAN Bin(袁 彬)，LIU Qiu—fang(刘秋芳)，and WANG Qian(王 倩) ABSTRACT Objective：To study the effect of Qingre Liyan Decoction(清热利咽汤，QRLYD)in the prevention and treatment of acute radiative oraI mucositis(AROM)，and to explore the mechanism of QRLYD by detecting epidermal growth factor(EGF)and T lymphocytes(CD3，CD4，and CD8)． Methods：Sixty patients conforming with the standard were randomly assigned to two groups．30 patients in each group．Patients in the triaI group were treated with QRLYD．and those in the controI group were treated with Dobell。s solution．both groups receiving conventionaI radiation treatment．The treatment course for both groups was 6 weeks on average．BIood routine test，CD3，CD4，and CD8 in the peripheral blood and EGF in the saliva were detected one day before and on the 1 4th and 28th day of radio—therapy．Results：Patients in the triaI group were in good condition with normaI spirits and intake of food and drinks．The incidence of AROM is Iower and the effect in preventing AROM is higher in the triaI group than those in the controI group(P0．O5)．The EGF in saliva，and CD4 and CD8 in the blood of patients in the triaI group were higher than those in the controI group(P0．05)． Conclusion：QRLYD can cure and prevent AROM．The mechanism may be related with its effects in enhancing body immunitV and promoting salivary EGF． KEY WORDS Qingre Liyan Decoction，acute radiative oraI mucositis，epidermaI growth factor，T lymphocytes MaIignant tumors in the head·neck region methods to prevent and cu re AROM，but so far account for 1 0％．30％ of aII kinds of maIignant there is still no widely