为更早识别阿尔茨海默病：阿尔茨海默病.pdf

中国现代神经疾病杂志 年 月第 卷第 期 2014 4 14 4 ChinJContempNeurolNeurosurg,April2014,Vol.14,No.4 ·277 · 神经影像学全球性研究计划 · · 为更早识别阿尔茨海默病：阿尔茨海默病 神经影像学计划简介 齐志刚 李坤成 王军 【 】 鉴于阿尔茨海默病给现代老龄化社会带来的巨大经济和心理压力，对其进行的基础与临 摘要 床研究具有重大经济与社会意义。阿尔茨海默病神经影像学计划作为目前国际上开展的最为成功的多 中心、跨学科纵向研究，已在阿尔茨海默病研究领域取得了较为突出的成就，本文简单介绍该项研究计 划，希望对国内同行有所借鉴。 【 】 阿尔茨海默病； 磁共振成像； 正电子发射断层显像术； 综述 关键词 To differentiate Alzheimers disease earlier: introduction of Alzheimers Disease NeuroimagingInitiative (ADNI) 1 1 2 QIZhi⁃gang,LIKun⁃cheng,WANGJun 1Department of Radiology, Xuanwu Hospital, Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Capital Medical University, Beijing 100053, China 2 College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing 100044, China ： Corresponding author LI Kun cheng (Email: cjr.likuncheng@) ⁃ 【 】 Abstract Alzheimers disease (AD) brought about much pressure in modern aging society both economically and psychologically, so it is meaningful to carry out AD research. Being considered as the mostsuccessfulmulti⁃center,inter⁃disciplinaryandlongitudinalresearchinADfield,AlzheimersDisease Neuroimaging Initiative (ADNI) has obtained outstanding achievements. In this review, we attempt to introducetheresearchplanofADNIprojectforreference. 【 】 Key words Alzheimer disease; Magnetic resonance imaging; Positron⁃emission tomography; Review This studywassupportedbyNationalNaturalScienceFoundationofChina(No81271556) andKeyProjectofBeijingScienceandTechnologyPlan(No.Z101107052210002). 近年来，“A