门冬胰岛素与生物合成人胰岛素治疗新诊断Ⅱ型糖尿病的对照研究.pdfVIP

实Jjj临床医药杂志 . 144 . Joumal of Clinical Medicine in Practice 2012 年第 16 卷第 21 期 门冬膜岛素与生物合成人膜岛素治疗 新诊断 H 型糖尿病的对照研究 陈中英 (江苏省吁H台人民医院药剂科，江苏淮安， 211700) 摘 要:目的 比较门冬膜岛素与生物合成人膜岛素治疗新诊断H 型糖尿病的临床疗效。方法 将新诊断的 96 例 H 型 糖尿病患者随机均分为2 组，分别为门冬膜岛素(治疗)组和生物合成人膜岛素(对照)组。患者分别在每日餐前给予皮下注射 门冬膜岛素和生物合成人膜岛素，且均每晚定时皮下注射一次甘精膜岛素c 比较 2 组患者血糖、低血糖事件、膜岛素用量的差 异。结果 用药后j 2 组餐前及餐后的血糖含量均明显降低，目门冬膜岛素组餐前、餐后血糖均低于生物合成入自夷岛紊组;门冬 膜岛素组患者低血糖发生次数低于生物合成人膜岛素组，差异有统计学意义;但 Z 结I膜岛素用量无显著差异。结论 门冬膜岛 素能够更好地控制H 型糖尿病的血糖，对H 型糖尿病的治疗更加有效。 关键词:门冬E夷岛素:生物合成人膝岛素; n 型糖尿病;血糖 中图分类号: R 587.1 文献标志码:A 文章编号: 1672 - 2353(2012)21 - 0144 - 03 Comparative study on c1 inical therapeutic effect of insulin aspart and biosynthetic human insulin in the treatment of newly diagnosed type 2 diabetes CHEN Zhougying CXuyi Peoρles Hosþital , Huui (L7/, Jiangsu , 211700) ABSTRACT: Objective To compare the clinical efficacy b巳tween insulin aspart and biosyn- thetic human insulin in the treatment of newly diagnosed type 2 diabetes. Methods Ninet y- six newly diagnosed type 2 diabetic patients were randomly divided into insulin aspart group (treatment group , n = 48) and biosynthetic human insulin group (control group , n = 48). The patients re ceived subcutaneous injection of insulin aspart or biosynthetic human insulin before daily meals , and they were treated with insulin glargine at the bedtime. The bl∞d sugar levels , incidence of hypo- glycemic episodes and the dosage of insulin were compared between the two groups. Results After administration of the drugs , the bl∞