Effects of Growth Retardation in Human Blastocysts on Implantation人类胚泡着床的影响.pdf

Page 4 - Fertility Weekly - September 23, 2013 characteristics of the patients or the clinics, wrote Tjon-Kon-Fat et al. (Inter-clinic variation in the chances of natural conception of subfertile couples, HR, 2013;5:1391-1397). Data was obtained from a previously reported prospective cohort study that included subfertile couples recruited in 38 clinics in the Netherlands (van der Steeg et al., 2007). After the current authors exclusions, 21 out of 38 clinics (n = 2916 couples) remained in this study. Study design was as detailed previously (van der Steeg et al., 2007). Duration of subfertility was defined as the time between the active wish to have children and the completion of fertility work-up. Female age was recorded at completion of fertility work-up. If a conception had occurred in either the current or a previous relationship of the female, this was considered secondary subfertility. Couples were followed from completion of the fertility workup. Statistical analysis included Kaplan-Meier survival curves, log-rank test, Cox proportional 2 hazards regression, ANOVA, χ test, likelihood ratio statistic (LR), empirical Bayes method (EB), a random effects model, and the aRegImpute multiple imputation function in Plus 6.0. P 0.05 was considered significant. Data were analyzed using IBM SPSS v.19.0 software or R for Windows v.2.13.0. The authors drew Kaplan-Meier survival curves of the 21 clinics that depicted the probability of an ongoing pregnancy for the 2916 couples from the beginning of the study to one year follow-up. The highest chance of ongoing pregnancy was 0