甲双胍不良反应文献探析.pdfVIP

评价与指南 Evaluation and Guide 二甲双胍不良反应文献分析 马满玲，郭美华，刘世萍，马妍妍，杨丽杰 哈尔滨医科大学附属第一医院药学部，黑龙江 哈尔滨 150001 [摘要] 目的：了解二甲双胍所致不良反应发生的情况并分析相关因素，为临床合理用药提供参考。方法：对二甲双胍所致的 64例不良反应文献进行分类统计与分析。结果：男女比例基本为1:1 ，平均年龄为(59.7 ±14.4)岁，53.1%的病例不合理用药， 56.3%的病例联合用药，临床类型以乳酸酸中毒为主(48.4%) ，其次为低血糖反应(25.0%) ，85.9%的病例治愈或好转，53.1%的 病例合并有其他疾病。结论：二甲双胍可引起较为严重的不良反应，甚至可致死亡，使用时须慎重考虑年龄、用法用量及合 并疾病等相关因素，做到合理用药，减少不良反应的发生。 [关键词] 二甲双胍；不良反应；合理用药 [中图分类号] R969.3 [文献标识码] A [文章编号] 1672-2809(2013)02-0022-05 A short review of adverse drug reactions caused by Metformin MA Man-ling, GUO Mei-hua, LIU Shi-ping, MA Yan-yan,YANG Li-jie Department of Pharmacy, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China [Abstract] Objective: To learn the adverse drug reactions caused by Metformin, relevant factors were analyzed in this review to provide a reference for clinical use of Metformin. Methods: 64 cases of Metformin-induced adverse drug reactions were statistically analyzed. Results: The ratio of adverse drug reactions occurred on Male to Female was about 1:1. Average age is(59.7 ±14.4)years old. Among these adverse reactions, 53.1% of which are with unreasonable drug use, 56.3% are with combined use of drugs. Clinical symptoms mainly were lactic acidosis (48.4%), followed by hypoglycemia(25.0%. 85.9% of these cases were cured, whereas 53.1% were combined other diseases. Conclusion: Since Metformin can cause severe adverse drug reactions (even death), it must be carefully used by considering the age, usage, dosage and other factors to reduce the incidence of adverse drug reactions. [Key words] Metformin; Adverse Drug Reaction; Rational Administration 由于人民生活水平提高、人口老龄化、生 析，同时对其临床用药合理性进行探讨，以便于对 活方式现代化、营养过剩等因素，糖尿 临床合理用药提供参考。 病患病率逐年上升，已成为常见病、多发病。糖尿 病目前病因未充分明确，尚无根本治愈之法。2 型 1 资料与方法 糖尿病逐年增加是全球范围的普遍现象，约占全部 1.1 资料来源及文献收集方法 利用“CNKI 中国知 糖尿病患者的90%以上[1] 。口服药物在2型糖尿病的 网”数据库，以“二甲双胍” 、“迪化糖锭” 、 治疗中占有重要地位，二甲双胍因疗效肯定，价格 “立克糖”、 “降