复方缬沙坦片中苯磺酸氨氯地平与缬沙坦的HPLC法测定.pdfVIP

292 • 小国民药工业杂志 Chinese Joumal of Phannaceuticals 2011 , 42 (4) 复方嫩沙坦片中苯磺酸氨氯地平与绷沙坦的 HPLC 法测定 杨大龙IA ，丁选梅l 句，卢定强1 .2 (1.南京工业大学药学院; 2. 南京工业大学江苏省药物研究所，江苏南京21∞09) 摘要z 建立了 HPLC 法测定复方缴沙饲片中的苯磺酸氨氯地平和缴沙坦。采用 C 色谱桩，流动相为 0.03 mol/L 磷酸二 1R 氧仰溶液(用 85%磷能调窒 pH 3.0)- 甲醇 (40 : 60) ，枪测波长237 nm. 苯磺酸氨氯地平和缴沙坦在3-7 和 48- 112μg!ml 浓度混罔内线性关系良好，凹收坦在为 99.8%和 99.6% ， RSD 为1.43%和1.02%. 关键词:苯磺自费氨氯地平:缴沙坝:复方编ìJ、坦片:高效液相色i曾1 测定 中团分樊号: 0657.7+2; TQ460.n j比献标志码:A 文意编号: 1001-8255 (201 1)04-0292-03 Determination ofAmlodipine Besylate and Valsartan in Compound Valsartan 丁ablets by HPLC 1 l 1 YANG Dalong DINGYimei 峙• LU Dingqiang .2 气 (1. hool ofPharmaceutical Sciences. N叫， ìng University ofTechnology; 2. Jiangsu 舟。vincial Institute ofMater.归 Medica， Nanjing University ofTechnology, Nanjing 210009) ABSTRACT: An HPLC method w制 estab!ished for the determination of amlodipine besyl脚and valsartan in the compound valsartan tablets. A CI8 column was used with the mobile phase of 0.03 moVL potassium dihydrogen phosphate solution (a司justed to pH 3.0 with 85% phosphoric acid)-methanol (40: 60) at the detection wavelength of237 nm. The calibration curves of amlodipine besylate and valsartan were linear in the ranges of 3刁 and 48斗12μglml.咀le average recoveries were 99.8% and 99.6% , with RSDs of 1.43% and 1.02%. Key Words: amlodipine besylate; valsartan; compound valsartan tablets; HPLC; determination 苯硝酸氨氯地平 (aml