微小RNA参与心肌缺血再灌注损伤的研究新进展.pdfVIP

• 584 . 上海交通大学学报(医学版) JOURNAL OF SHANGHAI JIAO TONG UNIVERSITY (MEDICAL SCIENCE) Vo l. 36 No.4 Apr. 2016 综述 微小 RNA 参与心肌缺血再灌注损伤的研究新进展 杨阳，如l 益，丁芳宝 上海交通大学医学院附属新华医院心胸外科，上海 200092 [摘要]心肌缺血再灌注损伤(MIRI)是指缺血心肌在恢复血流灌注后，表现出一系列心肌功能的障碍和结 构的损害。近年来的研究发现，多种微小 RNA( miRNA) 在 MIRI 进程中出现上调或下调的表达异常，并可通 过作用于靶基因调控下游的信号通路，引起相应蛋白表达的变化，从而参与调控 MIRI 的进程。而通过技术 手段上调或下调目标 miRNA 的表达可起到缓解 MIRI 的作用，且miRNA可作为急性心肌梗死的生物标记物， 反映疾病的严重程度及预后。该文主要就 miRNA 在 MIRI 中的作用机制、临床应用等方面的新进展加以 综述。 [关键词]微小 RNA; 缺血再灌注损伤;心肌保护 [DOIJ 10. 3969/j. issn. 1674-8115.2016.04.025 [中图分类号] R54 1. 4 [文献标志码] A New research progresses of micro-RNAs involving in myocardial ischemia reperfusion injury YANG Yang , LIU Yi , DING Fang-bao Depαrtment 01 cαrdiothoracic Surgery, Xinhuα Hospital， Shαnghai Jiαo Tong University School 01 Medicine , Shαnghαi 200092 [Abstract) Myocardial ischemia reperfusion injury (MIRI) , which occurs after reperfusion of ischemic myocardium , presents a series of myocardial functional disorder and structural impairments. In recent years , researchers have found abnormal up-re俘I!ated or down-re思llated expressions of many micro-RNAs (miRNAs) during the course of MIR I. By targeting specific genes , m iRNAs can modulate downstream signaling pa出ways and cause changes in expressions of corresponding proteins , thus involve in the process of re伊lating MIR I. MIRI can be alleviated by up-regulating or down-regulating expressions of target m iRNAs via technical approaches. As biomarkers of acute myocardial infarction , m iRNAs can reflect the severity and prognosis of the disease. This paper reviews new research