仿生材料的研究与制备以及在医学中的应用.ppt

Thank you! * * * * * Buddy Ratner slide Catheters Ear Eye Cheek Chin Testicle Dacron? Felt (for anchoring) PDMS penile implant 1950s to 1970s The next implants and devices were developed by MDs and engineers, usually working together (but occasionally alone). They were made of specially synthesized or processed materials (including animal and fish parts!) ? hard and soft contact lens ? silicone body parts ? artificial skin ? degradable sutures ? drug delivery devices Buddy Ratner slide “Artificial” skin, really a burn dressing, was an early example of tissue engineering An artificial skin burn dressing made of a combination of natural and synthetic polymers, ca. early 1970s. Developed by Ionnis Yannas, PhD (MIT) and John Burke, MD (Mass General Hospital) 1950s to 1970s The next implants and devices were developed by MDs and engineers, usually working together (but occasionally alone). They were made of specially synthesized or processed materials (including animal and fish parts!) ? hard and soft contact lens ? silicone body parts ? artificial skin ? degradable sutures ? drug delivery devices Degradable polyglycolic acid (PGA) polymers and the degradable suture were developed by Ed Schmitt and Joe Frazza at Davis and Geck, a division of Cyanamid Co. in the mid-1970s. Ethicon Co. of JJ improved it by adding lactic acid to the polymer composition, licensed it from Cyanamid, and produced it commercially as Vicryl?, the PLGA degradable suture. Vicryl? (PGA) after 7 days in rat muscle Courtesy Ethicon Corp, (JJ) Vicryl? (PGA) after 56 days in rat muscle Courtesy Ethicon Corp, (JJ) Surgical removal of suture is unnecessary! Tissue Engineering Biodegradable porous scaffold Stem cells, chondrocytes, osteoblast, hepatocytes, endothelial cells In vitro culture Four Milestones Scaffold design and fabrication Cell culturing and seeding in a static environment Growth of tissue in a dynamic environment Transplantation Tissue Engineering Sol Gel Temperature pH Sol-