偶联反应 课件.ppt

Beside the catalyst, other conditions are also crucial to the cross coupling reactions. The use of new technologies bring us new and fresh air. For example, the use of water and ionic liquids as solvents, would facilitates the experiments handle and the recycle of catalyst. The solid phase supported cross coupling reactions will facilitates the separation and recycle of catalyst. While the microwave assisted cross coupling reactions accelerated reactions proceed under relatively mild conditions. The flourish of cross coupling reactions also contain the contribution from china. The development of cross coupling reactions in china start at 1987, but a sharp increase can be found in recently years. After years development, the cross coupling reactions in china had taken up some space in the world. However in the most important progress I mentioned above, few was achieved in china. So we shall work even harder. At last, I’d like to conclude my lecture. In the past 40 years, the cross coupling reactions has made a series of remarkable progress. The introduction of the organometalic reagents start the developments, use of new less reactive organometalic reagents and activation of unreactive bonds bring the glory of cross coupling reactions. In the future, organohalide would like to be taken place by new substractes, the direct arylation would be perfect project. All the progress contributed to the development of the catalyst, ligand and other conditions. In the world, the cross coupling reactions in the future would be broader, greener, and more efficitnt. At last, I’d like to give my Acknowledgement to my supervisor Mr. Shi for his kind encouragement and help. I’d like to thank Mr. Xi for his organometalic chistry lesson and kind help in his lab. Thank all the Professors and students in Institute of the Organic Chemistry. Thank all the All members in our lab. After the short introduction, it comes to the main part of the lecture: The evolution of cross-coupling