突触可塑性 Synaptic Plasticity.pptx

The Cell Biology of Synaptic Plasticity;Kelsey C. Martin;Synaptic Plasticity;Hippocampal Synaptic Plasticity;LTP;Presynaptic Mechanisms of Plasticity;Synapsins and synaptic vesicle mobilization;RIM proteins and synaptic vesicle docking and priming;Postsynaptic Mechanisms of Plasticity;Postsynaptic kinases in the spine: CaMKII and PKMζ (zeta);CaMKII（合成调控？）;PKMζ;PKMζ;Activity-dependent modulation of postsynaptic glutamate receptors;NMDARs;AMPARs;AMPARs traffic ;Stargazin;P sites of AMPAR;Activity-dependent modulation of postsynaptic glutamate receptors----Activity-modified residues continue to be discovered;Trans-Synaptic Signaling; the Synaptic Cleft;Role of CAMs in synaptic plasticity;Trans-synaptic signaling by retrograde messengers;Trans-synaptic signaling by retrograde messengers;The Tripartite Synapse: Glia and Synaptic Plasticity;Regulating Gene Expression Within Neurons During Plasticity;Signaling from synapse to nucleus to regulate transcription;Local protein synthesis;Local protein synthesis---- mRNA localization;Local protein synthesis---- initiation, CPEB;Local protein synthesis---- initiation, 4E-BPs;Local protein synthesis---- elongation;Local protein synthesis;Local protein degradation;Perspectives;Thank you!