可溶性细胞间黏附分子-1与不稳定型心绞痛病人预后的关系.pdfVIP

· 414 · South China Journal of Cardiovascular Diseases，December 2OO7．Vol 13．No 6 · 论 著· 可溶性细胞间黏附分子一1与不稳定型心绞痛 病人预后的关系 田国平，彭子敬 (南华大学附属第二医院心血管内科，湖南衡阳 421001) 摘要： 目的 探讨不稳定型心绞痛 (unstable angina pectoris，uA)病人外周血可溶性细胞间黏附分子 (soluble intercellular adhesion molecule一1，sICAM一1)水平及其与预后的关系。方法 uA组86例，稳定 型心绞痛 (stable angina pectoris，SAP)组22例。对照组2O名为体检健康者。入院24 h内或接受体检 时采集血标本。用酶联免疫吸附试验方法测定外周血sICAM．1水平。对比较uA组病人心肌梗死试验性 溶栓疗法危险评分与sICAM-1水平关系。随访30 d和90 d，统计心血管不良事件。结果 uA病人外周 血sICAM一1水平显著高于SAP病人 (P0．01)；uA病人sICAM．1水平随心肌梗死试验性溶栓疗法危险 积分的增高而增高；高sICAM一1组的不稳定型心绞痛病人近期心脏不良事件发生率明显升高 (P O．O1)。结论 外周血sICAM一1水平可反映uA病情危险程度，uA病人近期心血管不良事件与高外周血 sICAM一1水平有关。 关键词： 不稳定型心绞痛；细胞间黏附分子一1； 危险分层；预后 中图分类号：R541．4 文献标识码：A 文章编号：1007—9688(2007)06—0414—04 Relationship between level of peripheral blood sICAM-1 and prognosis of unstable angina patients TIAN Guo—ping．PENG Zi—jing (Department of Cardiology， e Second Affiliated Hospital of Nanhua University． Hengyang Hunan 421001． China) Abstract：Objectives To explore the clinical value of peripheral blood intercellular adhesion molecule．1 (slCAM-1) in prognosis evaluation and dangerous classification of unstable angina patients fUAP)．Methods 108 cases were chosen as study groups according to patient history， clinical symptoms， crcatinase ECG ， and coronary angiography (CAG)， and 20 healthy persons as normal control group．After blood samples of patients were collected in 24 hours after admission， the peripheral blood levels of sICAM一1 were measured through enzyme-linked immunosorbent assay(ELISA)．The serum levels of sICAM一1 were compared between the different groups divided by calculating the risk scores of thrombolysis in myocardial infarction trial (TIMI)．All UAP patients followed up