吉西他滨联合卡铂用于晚期鼻咽癌二线治疗的临床观察.pdfVIP

· 962· 肿瘤防治研究2007年第34卷第12期 临床应用 吉西他滨联合卡铂用于晚期鼻咽癌二线治疗的 临床观察 刘志辉，周文献，李永强，胡晓桦 Gemcitabine Plus Carboplatin as Second-line Chemotherapy in Patients with Advanced Na- sopharyngeal Carcinoma LIU Zhi-hui，ZHOU Wen-xian，LI Yong—qiang，HU Xiao-hua The First Department of Chemotherapy，Guangxi Tumor Hospital，Nanning 530021，China Abstract：Objective To evaluate the efficacy and toxicity of gemcitabine in combination with carboplatin as second—line treatment in the patients with advanced nasopharyngeal carcinoma(NPC)．Methods Eli— gibale patients with advanced NPC failed to previous cisplatin-based chemotherapy were analysed retro— spectively．These patients had a performance status of 0 to 2，and adequate liver or renal function，as well as measurabale disease．Chemotherapy was administered with gemcitabine，1，OOOmg／m ，intravenously in— fusion for 30 minutes in d1 and d8，followed by carboplatin，400mg／m2，intravenously infusion for 2 hours in day 1；treatment was repeated every 21 days．Efficacy and toxicity would be evaluated after the comple— tion of two cycles of chemoyherapy．Results A total of 32 patients treated in the period of January，2004 to March，2007 were involved in this study．Complete remission(CR)was observed in 4 patients (12．5 )，16 patients(50．0％)achieved partial remission，giving a total response rate of 62．5％．8 pa— tients achieved a stable status，4 patients suffered from progressive disease．Median time to progression (TTP)was 4．5 months．．Hematological toxicities were the predominant side effects with grade 3／4 leu— kopenia，thrombocytopenia were observed in 43．6％，21．8％of patients，respectively，4 febrile neutropenia occurred．Non-hematological toxicity was mild．Conclusion The combination of gemcitabine and carbopla— tin showed a promising results as second—line chemotherapy in patients with advanced NPC，which merits