周围型肺腺癌及淋巴结增大SCT征象与肿瘤微脉管形成关系的探讨.pdfVIP

· 1834· 中国医学影像技术2007年第23卷第12期 Chin J Med Imaging Technol，2007，Vol 23，No 12 Correlative study of spiral CT features and angiogenesis in peripheral lung adenocarainomas and lymph nodes WANG Xue-qin，WANG Bin ，ZHANGShu-xian，FANZhen。 GUO Xin-quan，ZHANG Shi—zhuang (Medical Imaging Center，the Affiliated Hospital of Wei}ang Medical College，Weif口ng 261031，China) [Abstract] 0bjective To investigate the relationship between spiral computed tomography(SCT)features with tumor lymphangiogenesis,angiogenesis in peripheral lung adenocarainomas and lymph nodes．Methods Forty patients with surgi— cally and pathologically proved lung adenocarainomas and examined with plain and enhanced SCT scanning were included in the study．SP immunohistochemical technique was experimented in all pathologic specimens．According the immunohisto— chemical results of VEGFR-3 and CD34 to get the lymphatic microvessel density and microvessel density．The spiral CT fea— tures were compared and analyzed with immunohistochemical results of peripheral lung adenocarainomas．Results The cor— relation was shown respectively between lymph node metastasis and the value of LMVD and MVD．The CT feactures(CT enhancement degree，the diameter of tumor，lymph nodes growth，spiculated sign，spiculation，lobulation，blood vessel con- vergency，the diameter of lymph node，lymph node rim of fat，et a1．)were also relevant to the mean value of MVD and LM— VD．Conclusion Some SCT appearances(CT enhancement degree，the diameter of tumor，lymph nodes growth，spiculated sign，spiculation，lohulation，the diameter of lymph node，et a1．)were closely correlated with MVD，LMVD in lung adeno— carainomas，which could be a noninvasive method in predicting aggressiveness and metastasis． [Key words] Lung adenocarainomas；Immuno