维生素C胃漂浮片的研制.pdf

31 5 Vol. 31, No . 5 20 10 10 Journal of Hebei University of Science and T echnolo y Oct. 20 10 : 2010 C 岳红坤, 张敏燕 ( 石家庄学院化工学院, 河北石家庄 050035) : 研制了维生素C 胃漂浮片, 考察其漂浮和释药性能, 确定最优 方根据辅料性质及制剂 质量要求, 通过单因素试验确定影响维生素 C 胃漂浮片性能的主要参数, 然后通过正交试验确定 最佳 方及试验条件试验采用干粉直接压片制得维生素 C 胃漂浮片, 在人工胃液中考察其漂浮 性能并用滴定法检测其释药量研制的维生素 C 胃漂浮片的迟滞时间小于5 min, 持续漂浮时间 都大于 12 h, 其8 h 的累积释药量大于80% 结果表明所研制的维生素 C 胃漂浮片具有良好的漂 浮特性和释药性能 : 维生素C; 胃漂浮片; 漂浮和释药性能 : R9434 1 : A Preparation of vitamin C astric floatin tablet YUE Hon kun, ZH ANG Miny an ( Colle e of Chemical T echnolo y , Shijiazhuan University, Shijiazhuan Hebei 050035, China) Abstract: The research develops the astric f loatin sustained release tablet of vitamin C, studies its behavior of float in and release characterist ics and determ ines the optimal prescription. Accordin to the nat ure of adjuvant and quality of preparation and throu h the sin le factor experiments the main parameters w hich impact the properties of t he vit amin C astric floatin tab let were determined, and then throu h the ortho onal experiment the optimum prescription and experimental conditions were determ ined. T ablets were prepared by direct compression wit h dry pow der . Study of its floatin properties in the artificial as tric juice w as conduct ed and the dissolution of the astric floatin t ablet of vitamin C w as det ected by titration method. The be innin floatin t ime of vitamin C intra astric floatin sustained release tablets is less than 5 min, duration of floatin is more than 12 h, and the t otal dru release in 8 h is more t han 80 percent. T ablets prepared have ood behavior of f loat in and release characteristics. Key words:vitamin C; a