玛咖超临界提取物中抗衰老活性物质.pdf

Journal of Organic Chemistry Research 有机化学研究, 2017, 5(1), 45-50 Published Online March 2017 in Hans. /journal/jocr /10.12677/jocr.2017.51007 Anti-Aging Substances from Maca Supercritical Extract 1 1 1 2 2 1 Lihong Cheng , Yanfei Lin , Yanhui Wang , Pak Kum Ju , Kim Tae Seok , Lan Xiang , Yeo IK-Hyun2, Jianhua Qi1* 1 College of Pharmaceutical Sciences, Zhejiang University, Hangzhou Zhejiang 2 Institute of Food Culture, Pulmuone Co., Ltd., Seoul Korea th th st Received: Mar. 15 , 2017; accepted: Mar. 28 , 2017; published: Mar. 31 , 2017 Abstract Extracts of several products of Pulmuone were screened for their anti-aging activity using the K6001 yeast strain bioassay system. Maca supercritical extract significantly exhibited anti-aging activity and two active compounds were isolated from the extract. The structures were elucidated by the spectroscopic data and comparison with those reported. One structure was proposed to be n-benzyl-(9Z)-octadecenamide (1), and another was identified as n-benzylmyristamide (2). Both compounds significantly extended the replicative lifespan of K6001 yeast strain. To confirm the structure of compound 1, n-benzyl-(9Z)-octadecenamide (1) was synthesized and biological activ- ity was evaluated. The synthesized n-benzyl-(9Z)-octadecenamide (1) is identical to natural com- pound 1 from spectroscopic data and biological activity. Keywords Maca, Anti-Aging, Macamides, Yeast K6001 Strain 玛咖超临界提取物中的抗衰老 活性物质 1 1 1 2 2 1 2 1* 程丽红 ，林燕飞，王艳惠，朴金株，