Synergism and attenuation effects of Scapharca - 中国实验动物学报.DOC

毛蚶提取物作用研究王作军1 马玉奎2 贾玉萍2（1.山东省临朐县人民医院，临朐，山东262600；2.山东省药学科学院，济南，山东250033） 摘要 目的 研究毛蚶提取物和化疗药物合用后有无增效和减毒作用。方法 采用人肺癌A549细胞株裸鼠移植瘤模型，通过检测抑瘤率、体重、摄食量、血液学和血液生化学等指标，全面评价毛蚶提取物和NP化疗方案合用后的增效减毒作用。结果 毛蚶提取物(125、250、500 mg·kg-1, i.g)与NP化疗方案合用比单用NP化疗方案抑瘤率明显提高，明显抑制化疗引起的体重减轻、摄食量减少、减轻化疗对血液系统和肝肾功能的毒。结论 毛蚶提取物对NP方案化疗具有明显的增效减毒作用。 关键词 毛蚶提取物；增效减毒；抑瘤率；化疗 Synergism and attenuation effects of Scapharca Subcrenata Extraction on NP chemotherapy WANG Zuo-jun1, MA Yu-kui2, JIA Yu-ping2, GAO Qing1 People’s Hospital of Linqu County, Shandong Linqu 262600, China; 2. Shandong Pharmaceutical Academy, Jinan 250033) 【Abstract】 Objective To investigate the synergism and attenuation effects of Scapharca Subcrenata Extraction on NP chemotherapy? in model mice. Methods The models of nude mice were induced with A549 cell line xenograft?. The tumor inhibiting rates, body weight, food intake, hematology and blood biochemistry index were determined to evaluate the synergism and attenuation effects of Scapharca Subcrenata Extraction (125、250、500 mg·kg-1, i.g) on NP chemotherapy? Results Compared with NP chemotherapy group, the tumor inhibiting rates, body weight, food intake, white blood cell number were increased and glutamate pyruvate transaminase, glutamic oxalacetic transaminase and urea nitrogen were decreased markedly in NP chemotherapy plus Scapharca Subcrenata Extraction groups. Conclusion Scapharca Subcrenata Extraction has a remarkable synergism and attenuation effects on NP chemotherapy. 【Key words】 Scapharca Subcrenata Extraction；Synergism and attenuation；tumor inhibition rate；chemotherapy[作者简介] （1969-），，研究方向： 药物不良反应检测。[通讯作者] 马玉奎 (1975-)，男，研究方向：评价。 E-mail：yukuima@。毛蚶(Arca Subcrenata Lischke)俗称毛蛤、麻蛤， 属软体动物，沿海 。毛蚶营养与药用价值，《神农本草经》。响异性物和甘草对胃溃疡均有一定的治疗作用，对胃溃疡有预防发生和。毛蚶肉经低温提取纯化加工毛蚶多糖和毛