哌罗匹隆治疗原发性甲减所致精神障碍疗效观察.doc

(哌罗匹隆联合甲状腺素治疗原发性甲减所致精神障碍疗效观察 周芳珍，谢焱，程琳 (广西南宁市第五人民医院精神科，南宁 530001) 【摘 要】目的：探讨哌罗匹隆联合甲状腺素治疗原发性甲减所致精神障碍的疗效及安全性。方法：使用哌罗匹隆联合甲状腺素或左-甲状腺素钠片治疗甲减所致精神障碍34例，采用阳性和阴性症状量表(PANSS)及不良反应症状量表(TESS)于治疗前后进行评定，并在疗程结束后比较治疗前后血促甲状腺激素（TSH）、三碘甲状腺元氨酸（T3 ）、甲状腺素（T4）、游离三碘甲状腺元氨酸（FT3 ）、游离甲状腺素（FT4 ）的变化情况。结果：哌罗匹隆联合甲状腺素或左-甲状腺素钠片治疗后PANSS总分明显下降，治疗前与治疗后第2,4,8周比较差异有统计学意义(P0.01)。病情疗效评定：总有效率88.2%。治疗后TSH、T3、T4、FT3、FT4明显好转，与治疗前比较，差异有统计学意义(P0.01)。结论：哌罗匹隆是一种安全有效的抗精神病药物，对精神症状有显著的改善作用。联合治疗原发性甲减所致精神障碍病人是安全有效的。 关键词 哌罗匹隆 精神障碍 原发性甲减 甲状腺素 内分泌疾病 【中国图书分类法分类号】R581.1 【文献标志码】A 【收稿日期】 2012-3-7 Observation on the curative effects of Perospirone and with thyroxine in the treatment of mental disorders caused by primary hypothyroidism ZHOU Fangzhen ,XIE Yan,CHENG Lin (Department of Psychiatric,the Fifth People’s Hospital in Nanning) 【Abstract】Objective: To explore the curative effects and safety of Perospirone and with thyroxine in the treatment of mental disorders caused by primary hypothyroidism. Methods: Totally 34 patients with mental disorders caused by hypothyroidism were treated by Perospirone combined with thyroxine,or left - levothyroxine sodium tablets. The positive and negative symptom scale (PANSS) and adverse symptoms scale (TESS) were used to assess the curative effects before and after the treatment. The changes of blood thyroid stimulating hormone (TSH), iodine thyroid acid (T3), thyroxine (T4), free iodine thyroid acid (FT3) and free thyroxine (FT4) before and after the treatment were compared. Results: PANSS total scores were decreased significantly after treating by Perospirone combined with thyroxine,or left - levothyroxine sodium tablets, with significant statistical differences before the treatment and at 2, 4, 8 weeks after the treatment (P 0.01). Disease efficacy evaluation: the total effective rate was 88.2%. After the treatment, TSH, T3, T4, of FT3 and FT4 were significantly improved ccompared with those before treatment (P 0.01). Conclusions: Perospirone is a safe and eff