局部或区域晚期头颈鳞癌放化疗联合治疗现状和展望-中华临床医师杂志.pdf

中华临床医师杂志( 电子版)2013 年11 月第7 卷第22 期 Chin J Clinicians(Electronic Edition),November 15,2013,Vol.7,No.22 ·10227 · ·综述· 局部或区域晚期头颈鳞癌放化疗联合治疗现状和展望 李志勇 张艳清 郑艳群 朱步东 【摘要】 头颈部鳞状细胞癌的全身治疗包括细胞毒药物治疗（简称化疗）、靶向治疗和支持治疗；而 局部治疗主要包括放射治疗和手术。放化疗联合是局部晚期或区域晚期头颈部鳞癌主要治疗模式，包括同 步化放疗、诱导化疗、序贯化放疗。本文综述了原发于口腔、口咽、下咽、喉的鳞癌的化放疗联合治疗现 状和进展。 【关键词】 头颈部肿瘤； 治疗 The current status and future perspectives of the combined chemo-radiotherapy for locoregionally advanced squamous cell head and neck cancer LI Zhi-yong, ZHANG Yan -qing, ZHENG Yan-qun, ZHU Bu-dong. Department of Day Care, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital Institute, Beijing 100142, China Corresponding author: ZHU Bu-dong, Email: zhubd2008@ 【Abstract 】 The systemic treatments of locoregionally advanced squamous cell head and neck cancer include cytotoxic therapy (referred to chemotherapy), targeted therapies and supportive care, in addition to local therapy consisted of surgery and/or radiation therapy (RT). Approaches combining chemotherapy and radiation therapy is primarily treatment modalities in patients with locoregionally advanced head and neck cancer, comprising of concurrent chemoradiotherapy, induction chemotherapy and sequential chemoradiotherapy. This article reviews the current status and progress in the combined chemo-radiotherapy approaches to patients with locoregionally advanced head and neck cancer arising in the oral cavity, oropharynx, hypopharynx, and larynx. 【Key words 】 Head and neck carcinoma; Treatment 头颈部鳞状细胞癌（HNSCC ）的全身治疗主要包括细胞毒 的敏感性，克服对放疗的抵抗；并可减少放疗间歇时肿瘤细胞 药物治疗（简称化疗）、靶向治疗和支持治疗。局部治疗包括 再增殖，但增加放疗毒性，甚至延迟局部治疗的实施。SCRT 放射治疗（radiotherapy