多聚二磷酸腺苷聚合酶1与动脉粥样硬化-生物化学与生物物理进展.PDF

See discussions, stats, and author profiles for this publication at: /publication/272658133 PARP1 and atherosclerosis Article in rogress in Biochemistry and Biophysics · May 2012 DOI: 10.3724/S .J.1206.2011.00340 CITATION READS 1 15 3 authors: Qingwei Huo Dong-Feng Li South China Normal University South China Normal University 4 UBLICATIONS 2 CITATIONS 46 UBLICATIONS 244 CITATIONS SEE ROFILE SEE ROFILE Cheng Long South China Normal University 50 UBLICATIONS 652 CITATIONS SEE ROFILE Some of the authors of this publication are also working on these related projects: Myopathy related to mutation in voltage-gated calcium channel, Cav1.1 View project A modulates KCC2 expression and function in hippocampal GABAergic inhibition View project All content following this page was uploaded by Dong-Feng Li on 21 January 2016. The user has requested enhancement of the downloaded file. 生物化学与生物物理进展 Progress in Biochemistry and Biop hys ics 2012, 39(5): 423~428 聚二磷酸腺苷聚合酶 与动脉粥样硬化* 1 清伟 李东风 龙 程** ( 南师范大学生命科学学院，广州51063 1) 摘要 心血管疾病已经成为发达国家威胁生命的主要疾病，而动脉粥样硬化是最常见的心血管疾病之一 近来研究发现，多 聚二磷酸腺苷聚合酶 1(PARP 1)在动脉粥样硬化致病机理中起着重要的作用 PARP1 为PARP 家族中含量最丰富的核酶，担 负着DNA 缺口敏感酶的功能，具有双向作用 正常情况下，它参与DNA 损伤的修 ，但过量激活则消耗NAD+ 和ATP 使 细胞功能紊乱，最终坏死 一些疾病的细胞程序性死亡机制可能与此相关，这些疾病包括动脉粥样硬化、冠心病、糖尿病及 相关的心血管功能紊乱 有趣的是，除DNA 损伤激活PARP1 外，最近又发现激酶、多胺、咖啡因代谢物、茶碱和四环素等 也可以参与PARP1