166例乳腺癌患者临床病理学特征及其与预后的关系.pdfVIP

一 486一 重庆医科大学学报2008年第33卷第4期 (Journal of Chongqing Medical University 2008．Vo1．33 No．4) 文章编号：0253—3626(2008)04—0486-04 166例乳腺癌患者临床病理学特征及其与预后的关系 郭慧琳，张幸平 (重庆医科大学附属第一医院肿瘤科，重庆 400016) 【摘 要】目的：分析166例乳腺癌患者临床病理学特征，筛选预后不良因素，以指导临床治疗。方法：回顾性分析166例原发性 乳腺癌患者的临床资料，复习病理切片相关指标，分析患者临床病理学特征与预后的关系。结果：全组3年生存率为87．0％，5 年生存率为77．0％；3年局部复发率为7．1％，3年远处转移率为21．0％。单因素分析显示肿瘤大小、腋窝淋巴结转移情况、ER、 PR、绝经情况、组织学分级和临床分期对预后有影响；多因素Cox回归分析显示绝经情况、PR、淋巴结转移情况和组织学分级是 独立预后因素。结论：绝经情况、激素受体、淋巴结转移情况和组织学分级是乳腺癌独立预后因素。 【关键词】乳腺肿瘤；预后 【中国图书分类法分类号】R737．9 【文献标识码】B 【收稿日期】2007—09—25 CliniCOpathOlOgiCal features and their relationship with prognosis in 1 66 cases of breast cancer GUo Hui—lin。et al (Department of Ontology，the First Affiliated Hospital，Chongqing Medical University) 【Abstract】Objective：To study the relationship between clinicopathological and biological characteristics and prognosis in 166 patients with breast cancer．Methods：The clinicopathological data of 166 patients with primary breast cancer were analyzed retrospectively．The histological specimens were reviewed．The expression of ER and PR was assessed by immunohistochemistry． Results：Th e 3-year overall survival rate and 5-year survival rate were 87．0％ and 77．0％ ．respectively．The 3-year local recurrence rate was 7．1％．and the 3-year metastasis rate was 21．0％．The univariate analysis showed that the survival rate was related to the tumor size，lymph node involvement，ER，PR，menopause status，clinical stage and pathologic grade．The COX multivariate analysis identified that only menopause status，PR，lymph node involvement and pathologic grade were significant independent prognostic factors．Conclusion：Our analysis demonstrates that menopause status，PR，lymph node involvement and pathologic grade are significant independent prognostic facto