CXCR4在非小细胞肺癌中的表达及意义.pdfVIP

重庆医科大学学报2008年第33卷第4期 (Journal of Chongqing Medical University 20118．Vo1．33 No．4) 一 407一 论 著 文章编号：0253—3626(2008)04-0407-05 CXCR4在非小细胞肺癌中的表达及意义 李 醒，温剑虎 (重庆医科大学附属第一医院胸心外科，重庆 400016) 【摘 要】目的：探讨非小细胞肺癌 (Non small cell lung cancer，NSCLC)中CXC类趋化因子受体4(Chemokine CXC motif receptor 4，CXCR4)表达的意义，尤其是其表达在局部淋巴结转移中的作用。方法：未做治疗的41例NSCLC肿瘤原发灶、其中 25例转移淋巴结和2O例正常肺组织按SABC免疫组化法观察CXCR4的表达。结果：NSCLC原发灶中肿瘤细胞CXCR4表达阳 性率为92．68％，高于正常肺组织细胞CXCR4表达阳性率10％(P0．001 o不同临床特征NSCLC原发灶中肿瘤细胞CXCR4表 达没有差异(JP： O．05 o CXCR4表达强度与淋巴结转移也没有相关性(JP： O．05 o肿瘤细胞在淋巴结转移灶中CXCR4表达阳性率 96％，表达强度低于原发灶内( O．05 o结论：(1)不同组织学类型的NSCLC可能有共同的来源。(2)CXCR4高表达在NSCLC局 部淋巴结转移中可能仅决定转移的靶向。 【关键词】非小细胞肺癌；CXC类趋化因子受体4；淋巴结；转移；免疫组化 【中国图书分类法分类号】R730．2 【文献标识码】A 【收稿日期】2007—08—29 Reserch on expression of CXCR4 in non small cell lung cancer cells LI Xing，et (Department of Cardiac—thoracic Diseases，the First Affiliated Hospit01，Chongqing Medical University) 【Abstract】Objective：To explore the expression of CXCR4 in non small cell lung cancer(NSCLC)，and further to explore the meaning of CXCR4，especially the role of CXCR4 in regional lymph nodes metastasis in NSCLC． Methods：SABC immunohistochemical staining was used to observe the expression of CXCR4．The specimens were 41 cases of primary tumor tissues of NSCLC，25 cases of regional metastasized lymph nodes，and 20 cases of normal lung tissues．Results：The positive rate of the expression of CXCR4 was 92．68％ in primary tumor cells，and was higher than that in normal lung cells(P0．001)， which was only 10％ ．There was no significant difference of CXCR4 expression in primary tumor cells with different clini∞patholo cal characteristics(P0．05)．There was no significant correlation between the CXCR4 expression and the regional lymph nodes metastasis occurring(P0．05)．The positive expression rate of CXCR4 was 96％ in cancer cel