EphA7在胰腺癌组织中的表达及意义.pdfVIP

· 312 生 筮 鲞箍 期 ChinJPaucreatol。October2008．V01．8．No．5 · 论著 · EphA7在胰腺癌组织中的表达及意义 李德泉 吴河水 王琳 王琳芳 王春友 【摘要】 目的 检测EphA7蛋白在胰腺癌组织中的表达，探讨其与胰腺癌发生发展的关系。方 法 应用免疫组化方法检测 10例正常胰腺组织、51例胰腺癌及其配对癌旁组织中EphA7蛋白的表达， 并分析其与胰腺癌病理参数的关系。结果 正常胰腺组织、胰腺癌旁组织和胰腺癌组织中EphA7蛋白 的阳性表达率分别为 10％(1／10)、47．1％(24／51)和94．1％(48／51)，差异有显著性统计学意义 (P 0．05)。EphA7蛋白高表达与胰腺癌患者的年龄、性别、肿瘤部位、肿瘤大小无关(P0．05)，而与肿瘤 分化程度、临床分期、淋巴结转移或远距转移密切相关(P0．05)。结论 EphA7高表达可能与胰腺癌 的发生、发展及转移有关。 【关键词】 胰腺肿瘤；蛋白质酪氨酸激酶； EphA7 TheexpressionandsignificanceofEphA7in pancreaticcarcinoma LIDe—quan． He—shui．WANG Lin，WANGLin ng，WANGChun—you． CenterofPancreaticSu~eu，AffiliatedUnionHospital，Tongji MedicalCollege，HuazhongUniversityofScienceandTechnolog)，Wuhan 430022，China Correspondingauthor： He —shui，Emaif：whs1898@public．wh．hb．ca 【Abstract】 Objective ToinvestigatetherelationshipbetweenEphA7proteinandcarcinogenesisand developmentofpancreaticcancerbydetectingtheexpressionofEphA7proteininpancreaticcancertissues． M ethods TheexpressionofEphA7in10casesofnormalpancreatictissue，51easesofpancreaticcancerand itsadjacenttissuesweredetectedwithimmunohistochemicalmethodsandtherelationshipbetweenEphA7and pathologicfeaturesofpancreaticcancerwereanalyzed．Results TherateofexpressionofEphA7 protein in normalpancreatictissuewas10％ (1／10)，47．1％ (24／51)inadjacentpancreaticcancertissues，94．1％ (48／51)inpancreaticcancertissues．Thereweresignificantdifferenceamongthethreegroups(P0．05)． TherewasnosignificantcorrelationbetweentheexpressionofEphA7proteinandtheage，sex，tumorlocation， tumorsizeinpatientswithpancreaticcancer(P0．05)．Howevertherewassignificantcorrelationbetween theexpressionofEphA7proteinandthedegreeofdifferentiation，clinicalstaging，lymphnodemetastasis，or distantmetastasis(P0．05)．Conclusions TheabnormallyhighexpressionofEphA7mayberelevantwith theoccurrenceanddevelopmentofthepancreaticcancer． 【Keywords】P