4_苯氧基苯乙酮的合成研究.pdfVIP

2007 , 16( 3) : 232~ 2 34 A cta A g r ic ult ur ae B or eali-occ idental is S in ica * 4- 苯氧基苯乙酮的合成研究 * 吴绍东, 周文明 , 马海丹, 杨新娟, 陆勇芹 ( , 7 12 100) : , F riede-l Cr aft s 4- , : , 20 e , n ( ) B n ( ) B n ( ) = 1. 0 B 1. 2 B 2 . 4 , 4 h , 81% : F riede-l Craft s 4- : O 624 . 5 : A : 1004- 13 89 ( 2007) 03-0232- 0 3 Study on the Synthesis of 4-Phenoxyacetophenone W U Sh ao- dong, ZH OU W en- min g* , M A H a-i dan, Y A N G X in-j uan an d L U Y on g- qin ( C ol lege of Science , N ort hw est A F U niv ers ity , Y an gling Shaan x i 7 12 100, China) Abstract: 4- P henox yacet opheno ne w as pr ep ared via one step reactio n of Fr iedel- Craft s acelat ion, using dipheny l et her and acet yl chlo ride as t he mat erial. By sing le fact or ex periment s and ort hogo nal exp eri- m ent s, t he ef f ect s o f t he ratio of r eag ent s, t emp er at ure and solv ent on t he react ion w ere invest ig ated. T he opt imal react ion condit io ns w ere obt ained as fo llow s: n( diphenyl et her) B n( acet y l chlor ide) B n ( alum inium chloride anhydr ou s) = 1. 0 B 1. 2 B 2. 4 , car bon disulf ide as solv ent at 20 e . Af t er react ion fo r 4h , t he yield of t he pr odu ct reached abo ve of 81% . Key words: F riedel- Craft s acelat io n 4- phenox yacet ophenone A cet y l chlo ride D iphenyl ether 4- , , , , , , [ 1, 2] [ 3~ 5] 4- 4- , : ( ) , , U llmann