中药验方联合安理申对老年性痴呆的治疗研究.pdfVIP

重庆医学2008年4月第37卷第7期 697 · 论 著· 中药验方联合安理申对老年性痴呆的治疗研究 高长越 ，贾晓军 ，王延江 ，邓 娟 ，杨国汉。，周华东 (第三军医大学大坪医院：1．神经内科；2．中医科，重庆400042) 摘 要：目的 探讨中药验方与安理申联合使用对老年性痴呆患者认知功能和行为能力的改善作用。方法 收集老年性痴 呆患者160例，随机分为两组：安理中和中药验方联合治疗组8O例，安理申治疗组8O例。两组患者分别在治疗前、治疗 3个月 后、治疗6个月后进行 MMSE评分、ADL评分的测评。结果 中药验方与安理申联合使用治疗3个月后 MMSE评分为23、12， 较安理申治疗组有明显的改善作用(PO．01)。结论 中西药联合治疗对老年性痴呆患者认知、行为能力较单独应用安理申有 更为显著的治疗作用。 关键词：中药验方；老年性痴呆；安理申 中图分类号：R749．16；R289．5 文献标识码：A 文章编号：1671-8348(2008)07—0697-02 Clinical observation on effect of combination of donepezil and traditional Chinese medicine empirical formula in treating old patients with Alzheimer S disease GA0 Chang—yue ，-，JA Xiao—jun ，WANG Yan—Jiang ，et al、 (1、Department of Neurology；2．Department of Traditional Chinese Medicine，Daping Hospital， Third Military Medical University，Chongqing 400042，China) Abstract：Objective To investigate the effect of combination of donepezil and traditional Chinese medicine empirical formula in treating old patients with Alzheimer S disease on cognitive function and behaviora1．Methods 160 patients with Alzheimer S disease were randomly divided into 2 groups：the group treated with donepezil，the group treated with donepezil and traditional Chinese medicine empirical formula to prevent Alzheimer S disease．MMSE Scale and ADL Scale of 2 groups Were assessed and compared before treatment and 3 months，6 months after treatment．Results The cognitive function and behavioral abilities were improved markedly in the group treated with donepezll and butylphthalide(PO．O1)、Conclusion Combination of donepezil and traditional Chinese medicine empirical formula can markedly ameliorate the cognitive function and behavioral abilities in patients with Alzhei— mer