慢肝与肝纤维化.pdf

BRAZ J INFECT DIS. 2012;16(1):9-14 The Brazilian Journal of INFECTIOUS DISEASES /locate/bjid Original Article Role of hyaluronic acid and laminin as serum markers for predicting significant fibrosis in patients with chronic hepatitis B a* b a a a a Feng Li , Chang-Lai Zhu , Hong Zhang , Hua Huang , Qun Wei , Xiang Zhu , Xiao-Yang Chenga aDepartment of Gastroenterology, Digestive Disease Research Center, Affiliated Hospital of Nantong University, China bDepartment of Electron Microscope, Nantong University, China ARTICLE INFO A B S T R A C T Article history: Objectives: The aim of this study was to evaluate the diagnostic performance of serum HA Received 31 March 2011 and LN as serum markers for predicting significant fibrosis in CHB patients. Accepted 11 May 2011 Methods: Serum HA and LN levels of 87 patients with chronic hepatitis B and 19 blood donors were assayed by RIA. Liver fibrosis stages were determined according to the Metavir Keywords: scoring-system. The diagnostic performances of all indexes were evaluated by the receiver Hepatitis B, chronic operating characteristic (ROC) curves. Hyaluronic acid Results: Serum HA and LN concentrations increased significantly with the stage of hepatic Laminin fibrosis, which showed positive correlation with