流感病毒的抗原变异.ppt

* * * * * * Quick diagnosis 快速诊断 Principle of Prophylaxis and Therapy防治方法 Protect 防护 Vaccine 疫苗 Medicine 药物 symptomatic treatment 对症治疗 * * Quality Life: Live better ― longer * * * * * * * * * * * * * * * * * * * * * * * * * * * * Diagnosis, Prevention Cure for Viral Infections 病毒诊断与防治 Diagnosis light microscope : inclusion body neutralization test; complement fixation test; immunodiffusion; HAI fluorescence microscope: immunofluorescence serologic examination Molecular diagnosis microscope electron microscope : virion PCR; southern/northern blotting * Sample Collection Acute phase Avoid contamination: antibiotics Transport store: low temperature Double serum samples * Isolation and culture Animal embryonated egg Cell prevention and cure immunoprophylaxis artificial active immunity artificial passive immunity antiserum, immunoglobulin antibody, Remedial vaccine vaccine medicine nucleoside analogue Viral proteinase inhibitor Chinese herbal medicine Interferon and IFN-inducer Ribozyme * Viruses Associated with Respiratory Infections 呼吸道感染病毒 Viruses Associated with Respiratory Infections 呼吸道感染病毒指一大类能侵犯呼吸道引起呼吸道局部病变或仅以呼吸道为入侵门户，主要引起呼吸道及呼吸道外组织器官病变的病毒。90%以上的急性呼吸道感染由该类病毒引起。 * A kind of virus, which can infect the respiratory tract and induce symptoms in respiratory tract and/or the other organs. More than 90 percents ARI (acute respiratory infection) is induced by these viruses. ? orthomyxovirus (正粘病毒) ? pathogen of influenza Influenza Virus 流行性感冒病毒 Outline Biological Properties 生物学特性 Pathogenicity 致病性 Immunity 免疫性 Laboratory Diagnosis 诊断方法 Prophylaxis and Treatment 防治方法 I. Biological Properties Size Shape Size 80-120 nm Shape spherical 球形 filiate 丝形 * Viral core 病毒核心 Viral envelope 病毒包膜 Biological Properties Structure Segmented (-)ssRNA Nucleoprotein(NP) RNA-dependent RNA polymerase Viral core (易发生基因重组) (具型特异性, Ag性稳定) Biological Properties Structure matrix protein (M1) lipid bila