胰蛋白酶抑制剂的结构与功能研究进展 - 食品科学.pdf

364 2013, Vol.34, No.09 食品科学 ※专题论述 胰蛋白酶抑制剂的结构与功能研究进展 1 2 1 1,* 王荣春 ，孙建华，何述栋，马 莺 (1.哈尔滨工业大学食品科学与工程学院，黑龙江 哈尔滨 150090 ； 2.黑龙江省科学院微生物研究所，黑龙江 哈尔滨 1500 10) 摘  要：胰蛋白酶抑制剂属于丝氨酸蛋白酶抑制剂家族，其生理功能与防病虫害有关。近年来胰蛋白酶抑制剂因其 独特的生理功能，如抗癌、抗病毒等，引起了广泛关注。本文对胰蛋白酶抑制剂的分类、典型的结构、功能及其提 取和研究方法进行阐述，并对其应用潜力和存在的问题进行讨论,以期为胰蛋白酶抑制剂的进一步研究提供一定的 参考。 关键词：胰蛋白酶抑制剂；蛋白结构；功能；应用 Recent Advance in Research on the Structure and Function of Trypsin Inhibitor 1 2 1 1,* WANG Rong-chun ，SUN Jian-hua ，HE Shu-dong ，MA Ying (1. School of Food Science and Engineering, Harbin Institute of Technology, Harbin 150090, China ； 2. Institute of Microbiology, Heilongj iang Academy of Sciences, Harbin 1500 10, China) Abstract ：The physiological function of trypsin inhibitor, a member of the family of serine protease inhibitor, is associated with preventing or combating diseases and insect pests. In recent years, trypsin inhibitor has attracted wide attention from researchers because of its unique physiological properties such as anti-cancer and anti-virus activity. In this paper, we review the classification, typical structure and functions of trypsin inhibitor. Besides, the application potential of some current methods to extract and purify trypsin inhibitor and problems exisitng in their application are introduced, aiming at providing references for further expolration of trypsin inhibitor. Key words trypsin inhibitor protein structure function application ： ； ； ； 中图分类号：TS20 1.2 文献标志码：A 文章编号：1002-6630(20 13)09-0364-05 doi:10.7506/spkx 100