病原相关分子模式和损伤相关分子模式在免疫炎症 - 国际口腔医学杂志.pdf

•172• 43  2 2016  3 国际口腔医学杂志 第 卷 期 年 月 病原相关分子模式和损伤相关分子模式在 免疫炎症反应中的作用 1 1 1 1 2 丁烨 任静宜 于洪强 周延民 于维先 1.吉林大学口腔医院种植中心； 2.吉林省牙发育及颌骨重塑与再生省重点实验室 长春 130021 [摘要] 病原相关分子模式（PAMP ）和损伤相关分子模式（DAMP ）是与免疫学息息相关的两个分子。DAMP是 组织或细胞受到损伤和低氧等因素刺激后释放到细胞间或血液循环中的一类物质；PAMP则是病原体上的分子结 构。两者均被模式识别受体（PRR ）识别引起免疫应答。目前，已经有研究表明，DAMP和PAMP与慢性炎症疾病 和自身免疫性疾病有关。本文就PAMP和DAMP分子在免疫炎症反应中的作用作一综述。 [关键词] 病原相关分子模式； 损伤相关分子模式； 模式识别受体； 免疫炎症反应 [中图分类号] Q 753 [文献标志码] A [doi] 10.7518/gjkq.2016.02.013 Roles of pathogen-associated and damage-associated molecular patterns in immune inflammatory response Ding 1 1 1 1 2 Ye , Ren Jingyi , Yu Hongqiang , Zhou Yanmin , Yu Weixian . (1. Dept. of Implant Center, Hospital of Stomatology, Jilin University, Changchun 130021, China; 2. Key Laboratory of Mechanism of Tooth Development and Jaw Bone Remodeling and Regeneration in Jilin Province, Changchun 130021, China) This study was supported by the Fund of Jilin Province Development and Reform Commission(2013C022-4). [Abstract] Pathogen-associated molecular patterns(PAMP) and damage-associated molecular patterns(DAMP) are two molecules closely linked to immunology. DAMP are defined as a class of substances released to the cell or blood supply upon stimulation by tissue damage, cell hypoxia, or other factors. PAMP form the molecular structure of the pathogen. Both of these molecules are identified by pattern recognition receptors, which leads to the immune response. To date, research shows that DAMP and PAMP are