involvement of ca2+ in the apoptotic process – “friends or foes”.pdf

R e v i e w Involvement of Ca2+ in the Apoptotic Process – “Friends or Foes” Yossi Anis, Ph.D. Over the past two decades, the ubiquitous position of Ca2+ signaling in cellular apoptosis has been carefully investigated. The body of work described here highlights the complex role played by Ca2+ in generation, regulation and coordination of apoptosis. The word ‘apoptosis’ is derived from a Greek word stimulated by DNA damage, oxidative stress, different subcellular localizations and create meaning ‘falling leaves’ and is used to describe treatment with cytotoxic drugs or irradiation, a wide range of spatial and temporal signals. a form of cell death occurring in multicellular interruption in cell cycle signaling and death Cytosolic Ca2+ has been implicated in the activity organisms. It is defi ned as programmed cell death receptor ligands (TNF and Fas ligand). Cell of Ca2+/calmodulin-dependent protein kinase that involves altruistic suicide of individual cells signaling modulators, such as the universal (CaMK), protein kinase A (PKA) and C (PKC), 6 in favor of the organism as a whole. Apoptosis is protein kinase inhibitor Staurosporine (Fig. 1) mitogen-activated protein kinase (MAPK), and 7 10-14 2+ a tightly regulated, highly effi cient and energy- and the tyrosine kinase inhibitor Genistein are pho