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involvementofca2intheapoptoticprocess–“friendsorfoes”
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Involvement of Ca2+ in the Apoptotic
Process – “Friends or Foes”
Yossi Anis, Ph.D.
Over the past two decades, the ubiquitous position of Ca2+ signaling in cellular apoptosis
has been carefully investigated. The body of work described here highlights the complex
role played by Ca2+ in generation, regulation and coordination of apoptosis.
The word ‘apoptosis’ is derived from a Greek word stimulated by DNA damage, oxidative stress, different subcellular localizations and create
meaning ‘falling leaves’ and is used to describe treatment with cytotoxic drugs or irradiation, a wide range of spatial and temporal signals.
a form of cell death occurring in multicellular interruption in cell cycle signaling and death Cytosolic Ca2+ has been implicated in the activity
organisms. It is defi ned as programmed cell death receptor ligands (TNF and Fas ligand). Cell of Ca2+/calmodulin-dependent protein kinase
that involves altruistic suicide of individual cells signaling modulators, such as the universal (CaMK), protein kinase A (PKA) and C (PKC),
6
in favor of the organism as a whole. Apoptosis is protein kinase inhibitor Staurosporine (Fig. 1) mitogen-activated protein kinase (MAPK), and
7 10-14 2+
a tightly regulated, highly effi cient and energy- and the tyrosine kinase inhibitor Genistein are pho
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