海藻硫酸多糖抑制草酸钙结石形成的化学模拟chemical simulation on .pdf

2006 年第64 卷 化 学 学 报 Vol. 64, 2006 第7 期, 589～592 ACTA CHIMICA SINICA No. 7, 589～592 ·研究论文· 海藻硫酸多糖抑制草酸钙结石形成的化学模拟 邓穗平a 欧阳健明*,a,b 吴秀梅a 王凤新a 岑颖洲b (a 暨南大学生物矿化与结石病防治研究所 广州 510632) (b 暨南大学化学系 广州 510632) 摘要 用体外模拟方法研究了从海藻异枝麒麟菜中提取的硫酸多糖(ESPS)对尿结石患者尿液中草酸钙晶体生长的影 响. ESPS 不但诱导与尿路细胞膜粘附力较弱的二水草酸钙晶体形成, 而且抑制一水草酸钙的生长和聚集, 归因于一水 草酸钙的富钙( 101) 晶面与聚阴离子ESPS 之间的静电相互作用. 上述结果表明, ESPS 是一种抑制草酸钙结石的潜在绿 色药物. 关键词 草酸钙; 海藻多糖; 尿结石 Chemical Simulation on Inhibition of Calcium Oxalate Stones by Eu- cheuma striatum Polysaccharide DENG, Sui-Pinga OUYANG, Jian-Ming*,a,b WU, Xiu-Meia WANG, Feng-Xina CEN, Ying-Zhoub a ( Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632) b ( Department of Chemistry, Jinan University, Guangzhou 510632) Abstract The influence of sulfated polysaccharide (ESPS) isolated from marine algae Eucheuma striatum on crystallization of calcium oxalate crystals was investigated in urine of lithogenic patient in vitro. SPS could inhibit the growth and aggregation of calcium oxalate monohydrate (COM) and induce the formation 2＋ of calcium oxalate dihydrate crystals due to the strong electrostatic interactions between the Ca -rich ( 101) crystal faces of COM and the polyanionic polysaccharide. This result indicated that SPS may b