卵巢癌相关转移基因的研究进展 - tumor - 肿瘤.pdf

肿瘤2014 年9 月第34 卷第9 期　TUM OR Vol. 34, September 2014　　 875 DOI: 10.3781/j .issn.1000-7431.2014.09.016 Copyright© 2014 by TUM OR Review 综述 · 卵巢癌相关转移基因的研究进展 朱银芳，谭布珍 南昌大学第二附属医院妇产科，江西南昌　330006 [摘要]　卵巢癌是死亡率较高的妇科恶性肿瘤，大部分患者就诊时已是晚期。卵巢癌的侵袭和转移是患者死亡 的主要原因之一，其发生过程复杂，涉及多个基因和多个因素的综合参与。近年来，随着对肿瘤转移研究的深 入，发现许多肿瘤转移相关基因在卵巢癌的侵袭和转移中具有重要作用。本文就肿瘤转移相关基因果蝇zeste 基 EZH 2 ）、基质金属蛋白酶2 （metrix metalloproteinases-2 ， 因增强子人类同源物2 （enhancer of zeste homolog 2 ， MMP -2 ）、结肠癌转移相关基因1 （metastasis-associated in colon cancer-1，MACC 1 ）、高迁移率族蛋白A2 （high mobility group A2 ，HMGA 2 ）在卵巢癌侵袭和转移过程中的研究进展作一综述。 [关键词]　卵巢肿瘤；肿瘤转移；基因 [中图分类号]　R737.31 [文献标志码] A [文章编号]　1000-7431 (2014) 09-0875-04 Advances in research on ovarian cancer-related metastatic genes ZHU Yin-fang, TAN Bu-zhen Department of Obstetrics and Gynecology, Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China [A BSTRA CT]　Ovarian cancer is the disease with a high mortality in gynecologic malignant tumors. Most patients had metastasis once diagnosed, and the invasion and metastasis are considered as the main reasons contributing to patients’ death. The process of invasion and metastasis is complicated, involving multiple genes and steps which are related to diverse elements. In recent years, with the more and more research in the mechanism of tumor metastasis, it has found that a great deal of genes plays a significant role in invasion and metastasis of ovarian cancer. In this paper, it reviews the important advances about the role of enhancer of zeste homolog 2 (EZH 2), matrix metalloproteinase-2 (MMP-2), metastasis-associated in colon cancer-1 (MACC 1) and hig