高迁移率族蛋白b1与脑损伤研究进展 - 中华神经创伤.pdf

中华神经创伤外科电子杂志2015年6月第 1卷第3期 ChinJNeurotraumaSurg(ElectronicEdition),June2015,Vol.1,No.3 ·173· ·专题笔谈· 高迁移率族蛋白B 1与脑损伤研究进展 1 2 孙恺 王翀 【摘要】 高迁移率族蛋白B 1(HMGB1)为真核细胞核内的一种高度保守的非组蛋白，既可以 由坏死的细胞释放出来，也可以由炎症细胞主动释放到细胞外来发挥致炎作用。近来，越来越多 的研究发现，HMGB 1在创伤性脑损伤、缺血性脑损伤和出血性脑损伤的发生发展过程中起到多种 重要作用。本文就HMGB 1 的概述及其在脑损伤病理机制当中发挥的作用予以综述。 【关键词】 高迁移率族蛋白B 1； 脑损伤； 脑卒中； 脑外伤 1 Research progress on high mobility group protein B1 and craniocerebral injury Sun Kai , 2 1 Wang Chong . Department of Neurosurgery, Weifang Medical University, Weifang 261053, Shan- dong, China; 2Department of Neurosurgery, Shandong Jining No. 1 Peoples Hospital, Jining 272011, Shandong, China Corresponding author: Wang Chong, Email: wangch2408@163.com 【Abstract 】 High mobility group box- 1 (HMGB1) is a highly conserved nonhistone nuclear protein that contributes to the architecture of chromatin DNA. HMGB 1 is actively secreted by inflammatory cells or released by necrotic cells into the extracellular milieu, where it might be involved in the triggering of inflammation. Nowadays, an increasing number of researches discovered that HMGB 1 do play an important role in the genesis and development process of traumatic brain injury, ischemic brain injury and hemorrhagic brain injury. This review summarized the overview of HMGB 1 and its roles playing in the mechanism of brain injury. 【Key words 】 High mobility group box- 1; Brain injury; Cerebrovascular disorder; Craniocerebral injury 高迁移率族蛋白B 1(high mobility group box- 1 protein ， 治疗脑损伤相关疾病提供依据。 HMGB 1)为真核细胞核内的一种高度保守的非组蛋白，于20 一、HMGB 1概述 世纪70 年代在小牛