金合欢醇羟基的溴取代反应研究 - 林产化学与工业.pdf

24 Vol.24 Supplement 2004 8 hemistry and Industry of Forest Products Aug. 2004 * 孙 震, 赵振东 , 李冬梅, 刘先章 ( 中国林业科学研究院林产化学工业研究所, 江苏 南京210042) SUN Z : , , :, 3 h, HBr, , , : ; ; :TQ351. 471;O624. 33 :A : 0253- 2417(2004) S0- 0069- 04 RESEAR H ON BROMOSUBSTITUTION OF HYDROXYL GROUP OF FARNESOL SUN Zhen, ZHAO Zhendong, LI Dongmei, LIU Xianzhang (Institute of Chemical Industry of Forest Products, CAF, Nanj ing 210042, China) Abstract: In this paper, farnesyl bromide is successfully synthesized by using the highly efficient halidereplacement reagent Ph PBr prepared in the lab, and the content of the bromide is analyzed w ith a chemical analytical method. 3 2 T ypical reaction conditions are: room temperature and 3 h in benzene as a solvent. Since Ph PBr is easy to be de 3 2 composed in the presence of water, the solvent used in the reaction shouldbe dried in advance. To get rid of HBr re sulted during the bromosubstitution, pyridine was added to salt it out. The solution was distilled after the reaction w as completed to remove the solvent, then hexane was added to resolve the bromide, and thus Ph PO produced dur 3 ing the reaction could be removed. T he reaction is easy to operate, with high yield, can be applied to other terpenols as w ell. Key words: farnesol; dibromotriphenylphosphine; bromosubstitution ,