(南京市第一医院) APE1.PPT

Introduction Cancer is a multifactorial disease that results from complex interactions between many genetic and environmental factors ； Human cancer can be initiated by DNA damage caused by UV, ionizing radiation, diet, tobacco exposure, and environmental chemical agents. Introduction Human have developed a set of complex DNA repair systems to safeguard the integrity of genome by defending harmful consequences of DNA damage ； About 150 human DNA repair genes have been identified to data. Among these pathways, the base-excision repair (BER) pathway, has been associated with risk of cancers . APE1 The human apurinic/apyrimidinic endonuclease (APE), APE1 ( also known as APE, APEX, and REF-1), is involved in the BER pathway . A total of 18 polymorphisms in APE1 have been reported , but the most extensively studied polymorphism is the T to G transversion (Asp148Glu, rs3136820) (Figure 1). Recently, many studies have investigated the role of the APE1 T1349G polymorphism in the etiology of cancers of various organs, including the lung, bladder, colorectal, breast, and others. However, the results of these studies remain inclusive. In consideration of the extensive role of APE1 in the carcinogenic process, we carried out a meta-analysis on all eligible case-control studies to estimate the overall cancer risk of APE1 T1349G polymorphism and to quantify the potential between-study heterogeneity. Materials and Methods Inclusion criteria: evaluation of the APE1 T1349G polymorphism and cancer risk; case-control studies; contain available genotype frequency. Data extraction The following data were considered: author name, year and country of the study, ethnicity, source of control groups (population- or hospital-based controls), genotyping method, and numbers of genotyped cases and controls； Different ethnic descents were categorized as European, Asian, or mixed that included subjects of more than one ethnicity . Statistical Analysis odds ratios (ORs) ;