(南京市第一医院) APE1.PPT

Introduction Cancer is a multifactorial disease that results from complex interactions between many genetic and environmental factors ； Human cancer can be initiated by DNA damage caused by UV, ionizing radiation, diet, tobacco exposure, and environmental chemical agents. Introduction Human have developed a set of complex DNA repair systems to safeguard the integrity of genome by defending harmful consequences of DNA damage ； About 150 human DNA repair genes have been identified to data. Among these pathways, the base-excision repair (BER) pathway, has been associated with risk of cancers . A