糖尿病性肾症における尿中酸可溶性蛋白の临床的意义 - j-stage .pdf

日腎誌 第XXVIII巻 第10号1986 金内雅夫 他7名 1329 糖尿病性腎症における尿中酸可溶性蛋白の臨床的意義 金 内 雅 夫*,澤井 冬樹*,平 山 俊英*,湯 村 文敏*,濱 口 尚重* 西浦 公章**,土肥 和紘**,石川 兵衛** Clinical significance of urinary acid soluble protein in diabetic nephropathy MASAO KANAUCHI, FUYUKI SAWAI, TOSHIHIDE HIRAYAMA, FUMITOSHI YUMURA TAKASHIGE HAMAGUCHI, KIMIAKI NISHIURA*, KAZUHIRO DOHI* and HYOE ISHIKAWA* Department of Internal Medicine, Oyodo Municipal Hospital * The First Department of Internal Medicine, Nara Medical University Key words: acid soluble protein (ASP), diabetic nephropathy, N-acetyl-ƒÀ-D-gluco- saminidase (NAG) Urinary acid soluble protein (U-ASP) concentration was measured in 105 diabetic patients and studied on the relations with urinary N-acetyl-ƒÀ-D-glucosaminidase (U-NAG) activities, serum ASP (S-ASP) concentration, glomerular filtration rate (GFR), HbA1 levels, diabetic retinopathy (Scotts classification) and complications of macroangiopathy. 1) U-ASP index (mg/g•ECr) was 204•}69 in diabetics without proteinuria, 245•}75 with intermittent protein- uria, 289•}116 with persistent proteinuria, and 740•}355 with renal insufficiency. U-ASP index showed a significant increase in all diabetic groups than normal control (106•}42 mg/ g•ECr). 2) U-NAG index was significantly elevated in all diabe