组蛋白乙酰化与哺乳动物生殖 - 中国细胞生物学学报.pdf

中国细胞生物学学报 Chinese Journal of Cell Biology 2017, 39(4): 523–528 DOI: 10.11844/cj cb.2017.04.0280 组蛋白乙酰化与哺乳动物生殖 1,2 1 1* 杨 慧 张昌军 刁红录 1 2 ( 湖北医药学院附属人民医院生殖医学中心, 十堰442000; 武汉大学中南医院, 武汉430071) 摘要 组蛋白乙酰化是表观遗传修饰方式之一, 在哺乳动物生殖活动中的作用至关重要, 它 参与哺乳动物精子发生、卵母细胞成熟和胚胎发育以及子宫内膜基质细胞蜕膜化等生殖过程。组 蛋白乙酰化水平和功能的异常可以导致生殖细胞生成障碍从而致使胚胎死亡, 还可影响子宫内膜 容受性和蜕膜化的发生。此外, 组蛋白乙酰化与胎盘的功能也密切相关。组蛋白乙酰化修饰的进 一步研究将为不孕不育病因的阐明和治疗提供理论基础, 对人类优生优育意义重大。 关键词 组蛋白乙酰化; 哺乳动物; 精子发生; 卵母细胞; 子宫内膜; 胎盘; 生殖 Histone Acetylation and Mammalian Reproduction 1,2 1 1* Yang Hui , Zhang Changjun , Diao Honglu 1 ( Reproductive Medicine Center, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, China ; 2Zhongnan Hospital of Wuhan University, Wuhan 430071, China) Abstract Histone acetylation is one of epigenetic modifications. It plays an important role in mammalian reproductive activity. It is involved in mammalian spermatogenesis, oocyte maturation, embryo development, endometrial stromal cell decidualization and other reproductive processes. Abnormal levels of histone acetylation and function can lead to germ cell formation disorders and cause embryonic death, also can affect the endometrial receptivity and decidualization. In addition, histone acetylation and placental function are also closely related. Further study of histone acetylation modification will provide the theoretical basis for the clinical infertility treatment, which is of great significance for better huma