新型外科植入用钛合金tznt 的生物相容性 - 中国有色金属学报.pdf

20 4 2010 4 Vol.20 No.4 The Chinese Journal of Nonferrous Metals Apr. 2010 1004-0609(2010)04-0756-09 TZNT 1 2 2 (1. 201620 2. 710016) Ti12.5Zr2.5Nb2.5Ta(TZNT) 3 Ti6Al4VTi6Al7Nb TA2 (700 45 minAC)αα β TZNT 0.683%(5%) TZNTTi6Al4V Ti6Al7Nb 3 (24 6 d)100% 0 Ti6Al4V Ti6Al7Nb TZNT TA2 4 8 TZNT 4 8 R318.08 A Biocompatibility of new titanium alloy TZNT for surgical implant application 1 2 2 LI Jun , LI Zuo-chen , CHEN Du-juan (1. School of Materials Engineering, Shanghai University of Engineering Science, Shanghai 201620, China; 2. Northwest Institute for Nonferrous Metal Research, Xi’an 710016, China) Abstract: The biocompatibility of a new titanium alloy Ti12.5Zr2.5Nb2.5Ta (TZNT) for surgical implant application was investigated by hematolysis test, cytotoxic test and subcutaneous implantation test. The three standard titanium alloys Ti6Al4V, Ti6Al7Nb and TA2 for surgical implant application were taken as contrast materials. TZNT subjected to the full annealing treatment (700 , 45 min, AC) is composed of a large number of lamellar α-phase clusters with different orientations and a small amount of β-phase between lamellar α-phase. The hematolysis test result shows that the hematolysis rate of TZNT is 0.683% (less than 5%), which indicates that the acute hematolysis cannot be induced by TZNT