胚胎晚期暴露脂多糖对中年cd-1 小鼠背侧海马sumo-3 含量的影响.pdf

安徽农业大学学报, 2017, 44(2): 214-217 Journal of Anhui Agricultural University [DOI] 10.13610/ki.1672-352x023 网络出版时间：2017/4/19 12:03:25 [URL] /kcms/detail/34.1162.S1203.046.html 胚胎晚期暴露脂多糖对中年 CD-1 小鼠背侧海马 SUMO-3 含量的影响 1 2* 杨启纲 ，陈贵海 (1. 安徽医科大学第一附属医院重症医学科，合肥 230022 ； 2. 安徽医科大学附属巢湖医院神经内科和全科医学科，合肥 238000) 摘 要：为探讨胚胎晚期暴露细菌脂多糖（LPS ）的中年 CD-1 小鼠背侧海马的类泛素化蛋白（SUMO-3）含 量有无年龄相关性改变。采用免疫组织化学技术检测LPS 暴露组和对照组CD-1 小鼠背侧海马DG 区、CA1 区和 CA3 区各亚层的SUMO-3 表达。结果表明，两组间各区各亚层的SUMO-3 含量无明显差异。 关键词：细菌脂多糖；免疫组织化学；背侧海马；类泛素化蛋白 中图分类号：R338.64; S865.13 文献标识码：A 文章编号：1672352X (2017)02021404 Effects of lipopolysaccharide on the SUMO-3 levels in doral hippocampus of middle-aged CD-1 mice during late embryon 1 2 YANG Qigang , CHEN Guihai (1. Department of Critical Care Medicine, the First Affiliated Hospital of Anhui Medical University, Hefei 230022; 2. Department of Neurology and General Practice, Chaohu Hospital Affiliated of Anhui Medical University, Hefei 238000) Abstract: To explore the SUMO-3 levels in different subregions of dorsal hippocampus (DH) in the mid- dle-aged CD-1 mice, we used immunohistochemical method to detect the expression of SUMO-3 in different DH subregions. The results showed that, in all sublayers of hippocampal DG, CA1 and CA3 regions, the SUMO-3 level of LPS-group was similar to those in the middle-aged mice of the control-group. There were no significant differences between the two groups in each sublayer of DG, CA1 and CA3 regions. Key words: bacterial lipopolysaccharide; immunohistochemical method; dorsal hippocampus; sma