那格列奈的多晶型与溶解度polymorphism and solubility of nateglinide.pdf

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那格列奈的多晶型与溶解度polymorphism and solubility of nateglinide.pdf

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那格列奈的多晶型与溶解度polymorphism and solubility of nateglinide

2007 65 Vol. 65, 2007 24 , ACTA CHIMICA SINICA No. 24, · · *,a b b a a (a 210097) (b 210009) B, H S . : S H B . B, H S 42.84, 28.44 29.14 kJ•mol1. , B, H, S X2 , . ; ; ; ; X Polymorphism and Solubility of Nateglinide LI, Gang*,a XU, Qun-Weib LI, Ruib CHENG, Yong-Kea HUANG, Chang-Gaoa a ( Testing Analysis Center, Nanjing Normal University, Nanjing 210097) (b College of the Medicine, Nanjing Medicine University, Nanjing 210009) Abstract The solubility values of three forms of nateglinide have been measured at different temperatures, and their enthalpies have been calculated. The results indicated that the solubility values of both S-form and H-form are large than that of B-form clearly. Moreover, a new X2-form of nateglinide was found and its amorphous form was prepared. Keywords nateglinide; polymorphism; solubility; diabetes; X-ray powder diffraction , , 2001 II (crystalline), . N-(-4-)-D- (polymorphism). . , , , , [5] [6] B H , . , S , 3 [7] [8] , . [13], , , . .