表皮生长因子受体egfr 及其信号传导 - 生命科学.pdf

第18 卷 第2 期 生命科学 Vol. 18, No. 2 2006 年4 月 Chinese Bulletin of Life Sciences Apr., 2006 文章编号：1004-0374(2006)02-0116-07 表皮生长因子受体EGFR 及其信号传导 吴健虹, 谢秋玲, 陈小佳, 洪 岸 * （暨南大学生物工程研究所，广州5 1 0 6 3 2 ） 摘　要：表皮生长因子受体(epidermal growth factor receptor ，EGFR)是ErbB 家族成员之一，具有酪 氨酸激酶活性，是一种重要的跨膜受体。EGFR 被配体激活后启动胞内信号传导，经过细胞质中衔接 蛋白、酶的级联反应，调节转录因子激活基因的转录，指导细胞迁移、黏附、增殖、分化、凋 亡，且与肿瘤的形成和恶化密切相关。本文对EGFR 的结构特性、几种重要的信号通路及各个信号通 路之间的交联，以及信号的衰减等方面的研究进展进行了综述。 关键词：表皮生长因子受体；信号传导 中图分类号：Q 25 7 　　文献标识码：A Epidermal growth factor receptor (EGFR) and its signal transduction WU Jian-Hong, XIE Qiu-Ling, CHEN Xiao-Jia, HONG An* (Bioengineering Institute of Jinan University, Guangzhou 510632, China) Abstract: Epidermal growth factor receptor is a member of ErbB family. It’s an important transmembrane receptor with signal-transducing tyrosine kinase activity. Activated EGFR induced by ligands start intracellular signal cascades composed of cytoplasmic enzymes and adapter proteins. The subsequent signal stimulate transcription factors and finally direct cellular responses, including migration, adhesion, proliferation, differen- tiation and apoptosis. The EGFR signal plays a fundamental role in the development and growth of many types of human tumour cells. In this article the structural properties of EGFR were described, recent research ad- vances on several signal pathways and the crosss-talk between them, and the attenuation of the EGFR sigal were reviewed. Key words: epidermal growth factor receptor ；signal transduction 表皮生长因子受体(epidermal growth factor 和发展过程中占了重要的地位。从1984 年EGFR 基 receptor, EGFR)是一种广泛分布于人体各组织细胞膜 因被首次克隆，20 年来的研究显示，EGFR 是治疗 上的多功能糖蛋白，是鸟