他汀类降脂药能降低缺血性脑卒中患者再发卒中风险.docVIP

他汀类降脂药能降低缺血性脑卒中患者再发卒中风险【摘要】 目的 观察他汀类药物在缺血性脑卒中二级预防中的作用。方法 将2006年以来在本院住院治疗的脑卒中/TIA患者60例随机分为他汀干预组和对照组。对照组仅接受康复治疗及危险因素治疗,干预组在对照组治疗基础上加用阿托伐他汀20 mg 1次/d治疗,观察3年内两组患者再发脑卒中/TIA,死亡以及其他心血管事件发生率。结果 干预组再发脑卒中/TIA,冠脉事件发生率低于对照组,而死亡率,脑出血发生率两组却无明显差异。结论 他汀类药物能有效预防脑卒中/TIA患者再发心脑血管事件的发生。 【关键词】 脑卒中/TIA;他汀类药物;二级预防 Effects of statins on second prevention of ischemic stroke and transient ischemic attack ZHANG Han-ying. Internal medicine department of Rong-cheng Hospital,Jie-yang City Guangdong,Jieyang 522000,China 【Abstract】 Objective To observe the effects of statins on second prevention of ischemic stroke and transient ischemic attack.Methods 60 cases with ischemic stroke or transient ischemic attack which were collected from March 2006 to January 2007 were divided into control group and statins-treating group randomly. The control group only received routine treating containing rehabilitation care and risk factors controlling. The statins-treating group received atorvastatin 20 mg qd except routine treating. The incidence ofischemic stroke/transient ischemic attack recurrence,death,other heart-cerebral vessel events were collected within 3 years. Results The incidence of ischemic stroke/ transient ischemic attack recurrence,coronary artery events in statins-treating group was lower significantly than in the control group,and no significantly deference was found in the incidence of death and encephalorrhagia between two groups.Conclusion Statins can reduce incidence of ischemic/ transient ischemic attack recurrence,coronary artery events. 【Key words】 Ischemic stroke/ransient ischemic attack;Statins;Second prevention 血脂异常是导致缺血性脑卒中和短暂性脑缺血发作(TIA)的危险因素之一,他汀类药物显著降低心脑血管疾病的发生和死亡[1]。2006年美国心脏病协会和美国卒中协会联合发布的缺血性脑卒中一级预防防治指南肯定了他汀类药物在缺血性脑卒中一级预防的地位[2]。然而,有关他汀类药物在脑卒中二级预防中的作用的临床研究相对较少。为此,笔者从2006年开始观察了缺血性脑卒中和TIA患者服用他汀类药物(阿托伐他汀)对这些患者3年内再发心脑血管事件以及死亡率的影响。现报告如下。 1 资料与方法 收集2006年3月至2007年1月份有脑卒中或TIA病史患者(头颅CT排除脑出血)60例纳入研究,年龄52～78岁,平均(64.5±6.5)岁,男女比例为47/13。按随机化原则将入选病例分为干预组和对照组,每组30例。两组