依倍大剂量冲击疗法对化疗相关性贫血疗效分析.docVIP

依倍大剂量冲击疗法对化疗相关性贫血疗效分析【摘要】 目的 观察依倍大剂量冲击疗法对化疗相关性贫血的疗效及不良反应。方法 将101例化疗后贫血患者随机分入试验组或对照组。试验组采用依倍大剂量冲击疗法,具体用法为第1天给予依倍 40 000 U,然后在第3、5、8、10、12、15、17、19天给予依倍10 000 U,每12 h1次,依倍总剂量为200 000 U。对照组采用依倍常规剂量法,具体为依倍40 000 U,皮下注射,每周1次,连续6次,依倍总剂量为240 000 U。所有患者均观察6周,每2周进行1次疗效评价。结果 试验组治疗2周后血红蛋白明显升高,对照组4周后血红蛋白明显升高;试验组的4、6周血红蛋白值均高于对照组(P0.05)。结论 依倍大剂量冲击疗法对化疗相关性贫血的疗效优于常规剂量法,不良反应无明显增加。 【关键词】依倍;化学治疗;贫血 The impact of high-dose erythropoietin therapy for chemotherapy-relatedanemia SUN Yan-wei,ZHANG Ai-li,CHI Yu-hua,et al.Department of medical oncology,Rizhao people’s hospital,Shandong ,Rizhao 276800,China 【Abstract】 Objective To observe the impact and adverse reactions of high-dose erythropoietin therapy for chemotherapy-related anemia.Methods 101 cases of anemia after chemotherapy were randomly divided into test group or control group.Test group were treated with high-dose erythropoietin therapy,the specific use for the first 1 day for rhEPO 40 000 U,and in the 3th,5th,8th,10th,12th,15th,17th,19th day given rhEPO10 000 U,every 12 hours one time,rhEPO total dose of 200 000 U.The control group were treated with conventional doses of erythropoietin law,in particular for Erythropoietin 40 000 U,subcutaneously,one time per week for 6 times,rhEPO total dose of 240 000 U.All patients were observed in 6 weeks,every 2 weeks a second efficacy evaluation.Results The test group after 2 weeks of treatment hemoglobin was significantly higher in the control group after 4 weeks was significantly higher hemoglobin;experimental group of 4,6 weeks hemoglobin values were higher(P0.05).Conclusion The impact of high-dose erythropoietin therapy for anemia associated with chemotherapy is superior to conventional-dose method,with no significant increase inside reactions. 【Key words】Erythropoietin; Chemotherapy; Anemia DOI:10.3760/cma.j.issn 1673-8799.2010.06.14 作者单位:276800山东省日照市人民医院肿瘤科(孙衍伟 张爱莉 迟玉华 丁兆军); 青岛大学附属医院肿瘤科(梁军 安永恒) 近几年来,在治疗化疗相关性贫血中,促红素(recombinant human erythropoietin,rhEPO)的应用日益广泛,