Clinicopathological significance of chemotactic factor IL-8, MCP-1 and MIP-1αexpressions in gallbladder carcinoma.pdfVIP
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Clinicopathological significance of chemotactic factor IL-8, MCP-1 and MIP-1αexpressions in gallbladder carcinoma
C-iniCopath0logiCaIsignificanceofchemotactic
factorIL一8,MCP一1andMIP—loexpressions
ingallbladderca
LiangZeng,XiaoyanWang,LixueZhou。,ChaoGuo。,ChunlinCai,JinshuWu
r
C
Department of Pathology,Hunan ProvincialTumor Hospital,The Affiliated Tumor Hospitalof Xiangya
n
MedicineSchoolofCentralSouthUniversity,Changsha41000,China
o
DepartmentofRehabilitationandDermatology,RenminHospitalofTulufan,Turpan83800,China
。DepartmentofHepatobiliarySurgery,HunanProvincialPeople’sHospital,Changsha410000,China
m
TheForthInfectionDepartment,TheFirstHospitalofChangsha,Changsha410011,China
a
Received:28June2013/Revised:20July2013/Accepted:15August2013
@HuazhongUniversityofScienceandTechnologyandSpringer-VerlagBerlinHeidelberg2013
Abstract Objective:Gallbladdercarcinomawas.oneofthemalignantIumorsjnfhedigestivesystem.characterizedby
hiohrecurrenceandinvasion.RecentresearchIndicateslhatchemotacticfactorssuchaslL-8,MCP一1andMIP一1ahave
playedanimportantroleinsuchaspectsasformulation,growth,shiftingoflhelumor,Theaimofthisstudywasloinvestigate
expressionsofIL-8.MCP.1andMIP.1aingallbladderadenocarcinomatissues.MethoOsGallbladderadenocarcinomaand
noncancerouslissueswereroutinelyformalin.fixedandparaffin—embedded.andinsituhybridizationassayforIL一8,MCP-1
andMIP.1QmRNA.Results:(1)ThepositiveratesorthescoringsoflL-8,MCP-1andMIP一1amRNAweresignificantlyhigher
inhumangallbladderadenocarcinomalhanlhoseInhumanchroniccholecystitis(P0.01).Thepositiveratesorlhescorings
oflhreefactorswerelowerinwel1.differentiatiatedgallbladderadenocarcinomalhaninpoorly-differenfiattedones,whereas
fherewasonlyonesignificantdifferencebetweenMCP.1mRNA(PO.05).Thecloselypositivecorrelationwerefoundamong
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