支气管镜下高频电刀术联合化疗治疗晚期肺癌的疗效观察.doc

支气管镜下高频联合化疗治疗老年非小细胞肺癌的疗效观察 彭春燕 彭清臻 厉银平 刘桂霞 胡小飞 付学明 [摘要] 目的：观察支气管镜下高频电刀术联合全身化疗治疗老年中央型非小细胞肺癌（NSCLC）患者的疗效。方法：将38例老年中央型非小细胞肺癌患者随机分为治疗组和对照组。治疗组对患者进行支气管镜下高频电刀烧灼切割术，并给予化疗，对照组单用化疗，两组化疗方案相同。比较两组患者气促分级、KPS变化、肺功能改善程度以及近期疗效、远期疗效的评价。结果：治疗组气促分级、肺功能，KPS 评分改善明显优于对照组。治疗组19例，1例完全缓解，部分缓解15例，有效率(84.21％)，明显高于对照组(57.89%)(P0.05)。治疗组中位生存时间，0.5年、1年生存率明显高于对照组，两组间比较差异有统计学意义(P0.05)。结论：经支气管镜高频电刀术联合化疗可有效解除气道阻塞，提高患者生活质量，近期疗效显著，中位生存率、一年生存率提高，值得临床推广。 关键词：支气管镜；高频电刀术；化疗；非小细胞肺癌 Bronchoscope under high frequency electric sabreplay chemotherapy curative effect observation of treatment of senile non-small cell lung cancer Chunyan PENG，Qingzhen PENG，Yingpin LI，Guixia LIU，Xiafei HU Department of Respiratory Medicine;XueMing FU，Anesthesia Department Xiaogan General Hospital,6 square street ,Xiaogan 432000, China [abstract] objective: to observe the bronchoscope under high frequency electric sabreplay joint systemic chemotherapy to treat senile central type the curative effect of patients with non-small cell lung cancer (NSCLC).Methods: 38 cases of elderly patients with central type of non-small cell lung cancer were randomly divided into treatment group and control group.Treatment group bronchoscopy was performed under the high frequency electricity knife cutting, burning and giving chemotherapy and chemotherapy alone in the control group, two groups of the same chemotherapy regimens.Compare two groups of patients with shortness of breath grading, KPS change, improve lung function and the recent curative effect evaluation, the comparison of the long-term curative effect.Results: the treatment group shortness of breath grading, pulmonary function, KPS score improved significantly better than the control group.Treatment group (19 cases), 1 case of complete remission, partial in 15 cases, efficient (84.21%), significantly higher than the control group (57.89%) (P 0.05).Treatment group (a median survival time is 0.5 years, 1 year survival rate is significantly higher than the control group, comparing diffe