茵陈四物汤加味治疗气血亏虚湿热瘀阻型冠心病稳定型心绞痛的临床探究.pdf

提 要 目的：观察茵陈四物汤加味治疗冠心病稳定型心绞痛疗效并探讨其机理。 方法：临床研究选择气血亏虚湿热瘀阻型稳定型心绞痛患者 60 例，随机将其分 为试验组和对照组各 30 例。对照组给予常规西药治疗；试验组给予茵陈四物汤加味 每日一剂，早晚两次分服，同时给予常规西药治疗。观察治疗前后两组临床疗效和实 验室检查变化，4周为一个疗程，共观察一个疗程。 结果：1.心绞痛疗效、心电图疗效、中医症候改善率均以试验组疗效占优势，两 组比较有显著性差异（P0.05、P0.01）。2.试验组血液流变学指标有不同程度的改 善（P0.05、P0.01）。3.实验组血脂代谢有明显改善（P0.05、P0.01），CRP有 明显改善（P0.01）。4.实验组硝酸甘油停减率明显优于对照组（P0.01）。 结论：茵陈四物汤加味具有益气健脾，养血活血化瘀，清热利湿的作用。治疗冠 心病心绞痛有良好的临床疗效，能明显缓解胸闷、胸痛等临床症状，改善心肌缺血， 其机制可能通过调节脂代谢，改善血液流变学，抑制炎性物质CRP的过度表达等起到 治疗作用。无明显不良反应。 关键词 稳定型心绞痛；气血亏虚；湿热瘀阻；茵陈四物汤加味；临床研究 The Clinical Research of YinChenSiWuJiawei Decoction to Coronary Heart Disease Stable Angina Pectoris on Both Qi and Blood Deficiency and Stagnant Dampness-heat Abstructing the Collaterals Type Speciality: the Clinical Discipline of Chinese and Western Integrative Medicine Author: Liu Xiaoxia Tutor: Pro.Zhang Shiliang Abstract Objective:To observe the clinical effect of YinChenSiWuJiaWei decoction to coronary heart disease angina pectoris on both Qi and blood deficiency and stagnant and dampness-heat abstructing the collaterals type,and explore the mechanism. Methods: In this thesis,60 cases of stable angina pectoris,which belonged to the both Qi and blood deficiency and stagnant and dampness-heat abstructing the collaterals type,were divided into(YinChenSiWuJiaWei decoction–group ，30 cases) and control group(30 cases). The treatment group took YinChenSiWuJiaWei decoction,one medicinal preparation every day,two times a day; At the same time,were given conventional western medicine.The control group took conventional western medicine only.Observing the clinical efficacy and laboratory examination of the two groups before and after the treatment for one