荆防蒺藜汤治疗慢性荨麻疹的临床及实验研究.pdf

提 要 目的：观察荆防蒺藜汤的临床疗效，探讨荆防蒺藜汤治疗慢性荨麻疹可能的作用 机理。方法：研究共分两部分。临床研究：将慢性荨麻疹患者 60 例，随机分为治疗 组、对照组各 30 例。治疗组内服荆防蒺藜汤，对照组内服氯雷他定颗粒，每周复诊 1 次，4 周为 1 个疗程，1 个疗程后观察结果。实验研究：观察荆防蒺藜汤对 4-AP 致 小鼠瘙痒及蛋清致大鼠足跖肿胀的影响。结果：治疗组总有效率 83.33%，对照组总 有效率 86.67%，两组比较差异无显著性（P ＞0.05 ）。实验结果显示，荆防蒺藜汤有 减少小鼠瘙痒次数，抑制大鼠足跖肿胀的作用。结论：荆防蒺藜汤具有良好的抗过敏， 止痒，抑制组胺释放，抗炎的作用，治疗慢性荨麻疹疗效确切，复发率低，不良反应 轻微，值得临床推广应用。 关键词 荆防蒺藜汤；慢性荨麻疹；临床观察；实验研究 The Clinical Obserwation and Experimental Study for Treatment chronic urticaria with Jing-Tang Specialty：Dermatology,Surgery of TCM Author ：Ziruli Tutor：Professor Zhang Xiaojie Abstract Objective: To investigate the Jing-Tang Tribulus terrestris the clinical efficacy of anti-Jing Tang Tribulus terrestris the treatment of chronic urticaria possible mechanism. Methods: The study is divided into two parts. Clinical research: 60 patients with chronic urticaria were randomly divided into treatment group and the control group of 30 cases. Oral treatment group Jing-Tang Tribulus terrestris, the control group for Loratadine Oral particles, a referral of the week, four weeks is a course of treatment, a course of treatment after observation. Experimental Study: To observe the anti-Jing Tang on Tribulus terrestris 4 - AP itching and egg white in mice induced by the impact of the foot swelling. Results: In the treatment group, the total efficiency of 83.33%, the control group, the total efficiency 86.67%, the two groups had no significant difference (P 0.05). Experimental results show that Jing-Tang Tribulus terrestris have anti-inflammatory, inhibiting the mast cells to release histamine role. Conclusion: Jing-Tang Tribulus terrestris has a good anti-allergic, anti-itching, inhibiting the release of histamine, anti-inflammatory role in the treatment of chronic urticaria is effective, low r