2型糖尿病患者降血糖药物的选择及应用策略（Selection and application of hypoglycemic agents in patients with type 2 diabetes mellitus）.doc

2型糖尿病患者降血糖药物的选择及应用策略（Selection and application of hypoglycemic agents in patients with type 2 diabetes mellitus） Selection and application of hypoglycemic agents in patients with type 2 diabetes mellitus Application, of, Anti-hyperglycemic, Drugs, for, Type,, Diabetes:, Strategy, Selection, and Ruijin Hospital Affiliated to Shanghai Second Medical University and Shanghai Institute of Endocrinology and metabolism Chen Mingdao Chen Ming-Dao Ruijin, Hospital, affiliated, to, Shanghai, Second, Medical, University, Shanghai, Institute, of, Endocrine, and, Metabolic, Diseases [Abstract] on the market, diabetes treatment drugs are numerous, and effective hypoglycemic drugs are only six categories. For patients with type 2 diabetes mellitus, the most appropriate antidiabetic drugs should be selected according to the condition of the disease, and the combination therapy should be taken as soon as possible. This article provides some brief guidelines and methods for physicians who are dealing with type 2 diabetes. Type 2 diabetes mellitus (DM) is a complex disease with multiple genetic factors and environmental factors. Beta cell secretory defects and insulin resistance are two main factors in pathogenesis, which vary in different patients with high heterogeneity. Type 2 diabetes need lifelong treatment, hypoglycemic drugs are essential, and there are many kinds of hypoglycemic drugs, so it is necessary to select suitable anti hyperglycemia prescription according to the condition. First, the types of anti hyperglycemic drugs (I) sulfonylurea insulin secretion agents: there are many kinds of these drugs: 1. toluene sulfonylurea, that is, D860. 30min appeared in the blood, 3 to 5h peak, t1/2 4~6 h, each 0.5g, the maximum dose should not exceed 3.0g per day, the larger dose can no longer increase the effect. 2. glibenclamide, that is, glibenclamide. Low price, strong hypoglycemic effect, long duration, but easy to induce hypoglycemia, the peak value of 3 to 4h, t1/2 is 5~7 h, th