MicroRNA与胶质瘤关系的研究进展.PDF

临床与病理杂志 2017, 37(6) J Clin Path ol R e s 1293 doi: 10.3978/j.issn.2095-6959.2017.06.037 View this article at: /10.3978/j.issn.2095-6959.2017.06.037 MicroRNA与胶质瘤关系的研究进展 张明1,2 综述 张金岭2,3 ，车峰远2,4 审校 (1. 山东医学高等专科学校附属医院神经内科，山东 临沂 276004；2. 临沂市脑肿瘤功能影像工程技术研究中心， 山东 临沂 276004；3. 临沂市人民医院肿瘤科，山东 临沂 276004；4. 临沂市人民医院神经内科，山东 临沂 276004) [摘　要] 胶质瘤是一种最常见的颅内肿瘤，约占所有颅内肿瘤的50% 。MicroRNA是一种长为 18~25 nt ，进化 上高度保守的内源性非编码小分子RNA 。实验证据表明microRNA 可通过调控其靶标基因参与的信 号通路，影响肿瘤的发生和发展，发挥类似于癌基因或抑癌基因的功能。与正常脑组织相比，多种 microRNA在许多胶质瘤组织中异常表达，为胶质瘤的诊断和治疗提供了新的策略。 [关键词] 微小RNA ；胶质瘤；分子标志物 Research progress of microRNA and glioma 1,2 2,3 2,4 ZHANG Ming , ZHANG Jinling , CHE Fengyuan (1. Department of Neurology, Affiliated Hospital of Shandong Medical College, Linyi Shandong 276004; 2. Image Research Center on Brain Tumor of Linyi City, Linyi Shandong 276004; 3. Department of Oncology, Linyi Peoples Hospital, Linyi Shandong 276004; 4. Department of Neurology, Linyi Peoples Hospital, Linyi Shandong 276004, China) Abstract Glioma is the most common intracranial tumor, accounting for about 50% of all intracranial tumors. MicroRNA is a 18~25 nt, highly evolutionarily conserved endogenous non-coding small RNA. Experimental evidence indicates that microRNAs can play a role in tumorigenesis or tumor suppressor by regulating the signal pathways involved in their target genes, which may influence the genesis and development of tumors. There is growing evidence that a variety of microRNAs are expressed abnormally in many gliomas compared with