自体血清滴眼液治疗准分子激光角膜屈光手术后丝状角膜炎-中国药房.PDF

自体血清滴眼液治疗准分子激光角膜屈光手术后丝状角膜炎的 临床观察 ＊ 曾 丽 （浙江省岱山县第一人民医院眼耳鼻咽喉科，浙江岱山 316200） 中图分类号 R988.1 文献标志码 A 文章编号 1001-0408（2015）29-4121-03 DOI 10.6039/j.issn. 1001-0408.2015.29.31 摘 要 目的：观察自体血清滴眼液治疗准分子激光角膜屈光手术后丝状角膜炎的临床疗效及安全性。方法：选取准分子激光角 膜屈光手术后丝状角膜炎患者46例（90眼），按随机数字表法分为对照组和观察组，各23例（45眼）。对照组患者给予清除丝状 物＋佩戴软性接触镜＋重组牛碱性成纤维细胞生长因子滴眼液治疗，观察组患者给予清除丝状物＋佩戴软性接触镜＋自体血清 滴眼液治疗，比较两组患者临床疗效、治愈时间、复发率及不良反应。结果：观察组患者治疗总有效率为93.3％，高于对照组的 82.2％，差异有统计学意义（P ＜0.05）；观察组治愈时间为（2.7±1.1）d ，较对照组患者治愈时间（3.5±1.2）d 有明显缩短，差异有统 计学意义（P ＜0.05）；观察组患者丝状角膜炎复发率为4.4％，对照组为15.6％，观察组显著低于对照组，差异有统计学意义（P ＜ 0.05）；治疗期间观察组和对照组患者分别发生角膜上皮水肿1例（1眼）和2例（2眼），差异无统计学意义（P ＞0.05）。结论：清除丝 状物＋佩戴软性接触镜＋自体血清滴眼液治疗准分子激光角膜屈光手术后丝状角膜炎总有效率高、治愈时间快、复发率低，且不 良反应少。 关键词 准分子激光角膜屈光手术；丝状角膜炎；自体血清滴眼液；疗效 Clinical Observation of Autoserum Eye Drops in the Treatment of Filamentosa Keratitis after Excimer Laser Corneal Refractive Surgery ZENG Li （Dept. of Ophthalmology and Otolaryngology ，Daishan County First People ’s Hospital ，Zhejiang Daishan 316200，China ） ABSTRACT OBJECTIVE ：To observe clinical efficacy and safety of Autoserum eye drops in the treatment of filamentary kerati- tis after excimer laser corneal refractive surgery. METHODS ：46 patients （90 eyes）with filamentary keratitis after excimer laser corneal refractive surgery were selected and randomly divided into control group and observation group with 23 cases （45 eyes）in each group. The control group was given clearing mesh+wearing soft contact lens+bFGF eye drops ；the observation group was giv- en clearing mesh + wearing soft contact lens + Autoserum eye drops. The clinical efficacy ，cure time ，recurrence rate and ADR were compared between 2 groups. RESULTS ：The total effective rate of observation group was 93.3％，which was higher than that （82.2％）of the control group ，with statistical significance （P ＜0.05）；the cure time of observation group was （2.7±1.1）d ，which was shortened significantly co