五倍子乙醇提取物对124 株表皮葡萄球菌体外抗菌活性的观察.pdf

·696· 中国中医药信息杂志 2004 年 8月第 11卷第 8期 五倍子乙醇提取物对124 株表皮葡萄球菌 体外抗菌活性的观察 李仲兴,王秀华,孟晓洁,杨敬芳,时东彦 (河北医科大学第二医院,河北 石家庄 050000) 摘要：目的 观察五倍子乙醇提取物对表皮葡萄球菌的体外抗菌活性。方法 采用新的中药抑菌实验方法对 五倍子乙醇提取物进行 124 株表皮葡萄球菌的最低抑菌浓度测定。结果 五倍子乙醇提取物对 43 株耐甲氧西林表 皮葡萄球菌(methicillin-resistant staphylococcus epidermidis,MRSE)和 81 株甲氧西林敏感的表皮葡萄球菌 (methicillin-sensitive staphylococcus epidermidis,MSSE)的 MIC 、MIC 分别为 0.072、0.072、0.288、0.144 50 90 mg/mL。结论 五倍子乙醇提取物对 124 株表皮葡萄球菌具有较强的抑菌力,说明五倍子是极具开发前景的抗感染 中药。 关键词：五倍子；乙醇提取物；耐甲氧西林表皮葡萄球菌；甲氧西林敏感表皮葡萄球菌；体外抗菌活性 中图分类号：R285.5 文献标识码：A 文章编号：1005-5304(2004)08-0696-03 Observation of in Vitro Antibacterial Activity of Galla Chinensis Ethanol Extractant against 124 Strains Staphycoccus Epidermidis LI Zhong-xing, WANG Xiu-hua, MENG Xiao-jie, et al (The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China) Abstract ：Objective To evaluate in vitro antibacterial activity of Galla Chinensis ethanol extractant against S. epidermidis. Methods Deterimination of antibacterial activity of Galla Chinensis ethanol extractant against 124 strains S. epidermidis was performed by using agar dilution method. The antibacterial activity of Galla Chinensis ethanol extractant was compared with decoction of Galla Chinensis. Results The antibacterial efficiency of Galla Chinensis ethanol extractant against 124 strains S. epidermidis was good. MIC50 and MIC90 of that against MRSE and MSSE were 0.072, 0.072, 0.288, 0.144 mg/mL respectively. Conclusion Galla Chinensis ethanol extractant had strong antibacterial activity against 124 strains S.